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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2007-9-4
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pubmed:abstractText |
QT prolongation is associated with increased risk of sudden cardiac death in the general population and in people exposed to QT-prolonging drugs. Mutations in the KCNH2 gene encoding the HERG potassium channel cause 30% of long-QT syndrome, and binding to this channel leads to drug-induced QT prolongation. We tested common KCNH2 variants for association with continuous QT interval duration.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:BenjaminEmelia JEJ,
pubmed-author:CamargoAmy LAL,
pubmed-author:D'AgostinoRalph BRBSr,
pubmed-author:DrakeJared AJA,
pubmed-author:GuoChao-YuCY,
pubmed-author:HirschhornJoel NJN,
pubmed-author:LarsonMartin GMG,
pubmed-author:LevyDanielD,
pubmed-author:MusoneStacy LSL,
pubmed-author:Newton-ChehChristopherC,
pubmed-author:O'donnellChristopher JCJ,
pubmed-author:SurtiAartiA
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pubmed:issnType |
Electronic
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pubmed:day |
4
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pubmed:volume |
116
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1128-36
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17709632-Adult,
pubmed-meshheading:17709632-Base Sequence,
pubmed-meshheading:17709632-Ether-A-Go-Go Potassium Channels,
pubmed-meshheading:17709632-Female,
pubmed-meshheading:17709632-Genetic Linkage,
pubmed-meshheading:17709632-Genetic Variation,
pubmed-meshheading:17709632-Haplotypes,
pubmed-meshheading:17709632-Humans,
pubmed-meshheading:17709632-Long QT Syndrome,
pubmed-meshheading:17709632-Male,
pubmed-meshheading:17709632-Middle Aged,
pubmed-meshheading:17709632-Molecular Sequence Data,
pubmed-meshheading:17709632-Polymorphism, Genetic,
pubmed-meshheading:17709632-Prospective Studies
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pubmed:year |
2007
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pubmed:articleTitle |
Common genetic variation in KCNH2 is associated with QT interval duration: the Framingham Heart Study.
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pubmed:affiliation |
National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Mass, USA. cnewtoncheh@partners.org
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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