Linked Life Data

17709123

Source:http://linkedlifedata.com/resource/pubmed/id/17709123

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-4-14
pubmed:abstractText
The effects of mycotoxin zearalenone and their major metabolites alpha- and beta-zearalenol on spontaneous contractions in isolated lamb uterine smooth muscle were examined. The study was carried out on 20 female prepubertal lambs aged between 45 and 50 days. Myometrial strips were set up in two isolated organ baths (10ml) at 37 degrees C and were exposed to increasing concentrations (10(-11)M-10(-6)M) of these mycoestrogens and results were compared with the effect, at the same concentrations, of natural estrogen 17beta-estradiol. Our findings suggest that mycotoxins and 17beta-estradiol, at nanomolar concentrations, rapidly enhance phasic spontaneous smooth muscle contraction. In particular, zearalenone increases the uterine activity similarly to 17beta-estradiol. On the contrary, its metabolite alpha-zearalenol significantly inhibits myometrial contractility.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0034-5288
pubmed:author
pubmed:issnType
Print
pubmed:volume
84
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
471-6
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Influence of mycotoxins on spontaneous contraction in myometrial strips of prepubertal lamb.
pubmed:affiliation
Department of Food Science, University of Teramo, Viale Crispi, 212, I-64100 Teramo, Italy.
pubmed:publicationType
Journal Article, In Vitro