rdf:type |
|
lifeskim:mentions |
umls-concept:C0034656,
umls-concept:C0043210,
umls-concept:C0087111,
umls-concept:C0177804,
umls-concept:C0205251,
umls-concept:C0232970,
umls-concept:C0282460,
umls-concept:C0339510,
umls-concept:C0917713,
umls-concept:C1414083,
umls-concept:C1530450,
umls-concept:C1690432,
umls-concept:C1826421,
umls-concept:C2699549
|
pubmed:issue |
12
|
pubmed:dateCreated |
2007-12-17
|
pubmed:abstractText |
Denosumab is a monoclonal antibody to RANKL. In this randomized, placebo-controlled study of 412 postmenopausal women with low BMD, subcutaneous denosumab given every 3 or 6 mo was well tolerated, increased BMD, and decreased bone resorption markers for up to 24 mo. Continued study of denosumab is warranted in the treatment of low BMD in postmenopausal women.
|
pubmed:commentsCorrections |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0884-0431
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
22
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1832-41
|
pubmed:dateRevised |
2008-8-5
|
pubmed:meshHeading |
pubmed-meshheading:17708711-Aged,
pubmed-meshheading:17708711-Alendronate,
pubmed-meshheading:17708711-Antibodies, Monoclonal,
pubmed-meshheading:17708711-Biological Markers,
pubmed-meshheading:17708711-Bone Density,
pubmed-meshheading:17708711-Bone Density Conservation Agents,
pubmed-meshheading:17708711-Bone Resorption,
pubmed-meshheading:17708711-Double-Blind Method,
pubmed-meshheading:17708711-Female,
pubmed-meshheading:17708711-Humans,
pubmed-meshheading:17708711-Middle Aged,
pubmed-meshheading:17708711-Osteoporosis, Postmenopausal,
pubmed-meshheading:17708711-Postmenopause,
pubmed-meshheading:17708711-RANK Ligand,
pubmed-meshheading:17708711-Time Factors
|
pubmed:year |
2007
|
pubmed:articleTitle |
Two-year treatment with denosumab (AMG 162) in a randomized phase 2 study of postmenopausal women with low BMD.
|
pubmed:affiliation |
New Mexico Clinical Research & Osteoporosis Center, Albuquerque, NM 87106, USA. lewiecki@aol.com
|
pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Clinical Trial, Phase II
|