Linked Life Data

17707811

Source:http://linkedlifedata.com/resource/pubmed/id/17707811

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2007-8-20
pubmed:abstractText
The immunosuppressive agent FK506 (tacrolimus) has neuroprotective properties in an experimental model of cerebral ischemia. To improve the accuracy of clinical studies in acute stroke, a clinical dose setting should be based on the brain concentration, but not on the blood concentration of agents in humans. We have already established a measurement method using PET for FK506 concentration in the normal monkey brain, which could be applicable for human study; however, under ischemic conditions, in this study, we aimed to examine the brain concentration of FK506 in a monkey model of stroke.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0969-8051
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
703-7
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
PET measurement of FK506 concentration in a monkey model of stroke.
pubmed:affiliation
The Medical and Pharmacological Research Center Foundation, Hakui City, Ishikawa 925-0613, Japan. murakami@mprcf.or.jp
pubmed:publicationType
Journal Article