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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
6
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pubmed:dateCreated |
2007-8-20
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pubmed:abstractText |
The activity of the pyrimidine salvage pathway enzyme thymidine kinase 1 (TK1) is tightly cell cycle regulated and has been investigated as a prognostic indicator of cancer in a variety of tissues. However, using the in vitro assay of TK1 to rank order a series of unique tumor samples by their TK1 activity can be problematic due to the complex nature of TK1 enzyme substrate kinetics. We present a refined TK1 in vitro assay and method of analysis which address these problems.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
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|
pubmed:issn |
0969-8051
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
34
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
619-23
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pubmed:meshHeading |
|
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pubmed:year |
2007
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pubmed:articleTitle |
A simple quantitative assay for the activity of thymidine kinase 1 in solid tumors.
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|
pubmed:affiliation |
Division of Nuclear Medicine, Department of Radiology, University of Washington School of Medicine, Box 356113, Seattle, WA 98195, USA. jsbrock@u.washington.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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