|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2008-12-26
|
|
pubmed:abstractText |
An association between memory performance in healthy young, middle aged an elderly subjects and variability in the KIBRA gene (rs17070145) has been recently described. We analyzed this polymorphism in 391 sporadic Alzheimer's disease (AD) patients and 428 cognitively normal control subjects. The current study reveals that KIBRA (rs17070145) T allele (CT and TT genotypes) is associated with an increased risk (OR 2.89; p=0.03) for very-late-onset (after the age of 86 years) AD.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
1558-1497
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
30
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
322-4
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:17707552-Aged,
pubmed-meshheading:17707552-Aged, 80 and over,
pubmed-meshheading:17707552-Aging,
pubmed-meshheading:17707552-Alzheimer Disease,
pubmed-meshheading:17707552-Female,
pubmed-meshheading:17707552-Genetic Predisposition to Disease,
pubmed-meshheading:17707552-Genetic Variation,
pubmed-meshheading:17707552-Humans,
pubmed-meshheading:17707552-Incidence,
pubmed-meshheading:17707552-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:17707552-Male,
pubmed-meshheading:17707552-Middle Aged,
pubmed-meshheading:17707552-Phosphoproteins,
pubmed-meshheading:17707552-Polymorphism, Single Nucleotide,
pubmed-meshheading:17707552-Proteins,
pubmed-meshheading:17707552-Risk Assessment,
pubmed-meshheading:17707552-Risk Factors,
pubmed-meshheading:17707552-Spain
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Age-dependent association of KIBRA genetic variation and Alzheimer's disease risk.
|
|
pubmed:affiliation |
Neurology Service, Marqués de Valdecilla University Hospital, University of Cantabria, Santander, Spain.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
