Source:http://linkedlifedata.com/resource/pubmed/id/17707070
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
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| pubmed:dateCreated |
2008-1-14
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| pubmed:abstractText |
Social affiliation-avoidance behaviors are essential indices of sociality. We examined changes in social affiliation-avoidance behaviors in an open-field apparatus while simultaneously measuring wheel-running activity. Recent studies suggest that mice increase wheel-running activity in stressful situations; thus, we hypothesized that wheel-running activity would reflect a state of social stress and avoidance. Mean duration of wheel-running increased significantly when mice were confronted with unfamiliar mice compared to cage mates. There were negative correlations between the amount of wheel-running and social affiliation indices. We also examined the effect of social defeat on wheel-running activity. Mice that had experienced social defeat significantly increased their wheel-running when an aggressor mouse was present. This social defeat-induced wheel-running activity was ameliorated by the administration of diazepam. Our results indicate that wheel-running activity is relevant to social affiliation-avoidance behaviors and may be a reliable index of anxiety induced by social stress.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
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| pubmed:issn |
0031-9384
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
28
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| pubmed:volume |
93
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1-7
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| pubmed:meshHeading |
pubmed-meshheading:17707070-Adaptation, Psychological,
pubmed-meshheading:17707070-Aggression,
pubmed-meshheading:17707070-Analysis of Variance,
pubmed-meshheading:17707070-Animals,
pubmed-meshheading:17707070-Anxiety,
pubmed-meshheading:17707070-Avoidance Learning,
pubmed-meshheading:17707070-Behavioral Research,
pubmed-meshheading:17707070-Corticosterone,
pubmed-meshheading:17707070-Displacement (Psychology),
pubmed-meshheading:17707070-Male,
pubmed-meshheading:17707070-Mice,
pubmed-meshheading:17707070-Mice, Inbred DBA,
pubmed-meshheading:17707070-Motor Activity,
pubmed-meshheading:17707070-Social Behavior,
pubmed-meshheading:17707070-Social Environment,
pubmed-meshheading:17707070-Statistics, Nonparametric,
pubmed-meshheading:17707070-Stress, Psychological,
pubmed-meshheading:17707070-Time Factors
|
| pubmed:year |
2008
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| pubmed:articleTitle |
Wheel-running activity increases with social stress in male DBA mice.
|
| pubmed:affiliation |
Department of Veterinary Ethology, University of Tokyo, Japan.
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| pubmed:publicationType |
Journal Article
|