Source:http://linkedlifedata.com/resource/pubmed/id/17706367
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2007-9-24
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| pubmed:abstractText |
Hippocampal granule cells (GCs) are continuously generated in the subgranular zone of the dentate gyrus (DG) and functionally incorporated to dentate neural circuits even in adulthood. This raises a question about the fate of neonatally born GCs in adult DG. Do they exist until adulthood or are they largely superseded by adult-born GCs? To investigate this question, we examined the contributions of postnatally born GCs to the adult mouse DG. C57BL/6 mice were grouped in three different postnatal (P) ages (group 1: P0, group 2: P7, and group 3: P35) and received a daily bromodeoxyuridine (BrdU) injection for three consecutive days (P0/1/2, P7/8/9, and P35/36/37, respectively) to label dividing cells. At 6 months old, hippocampal sections were prepared from the animals and immunostained with anti-BrdU antibody and an antibody against the homeobox prospero-like protein Prox1, a marker of GCs. We defined BrdU- and Prox1-double positive cells as newborn GCs and analyzed their density and distribution in the granule cell layer (gcl), revealing that newborn GCs of each group still existed 6 months after BrdU injections and that the density of GCs born during P0-2 (group 1) was significantly higher compared with the other groups. Although the density of newborn GCs in the each group did not differ between male and female, the radial distribution of them in gcl showed some differences, that is, male newborn GCs localized toward the molecular layer compared with female ones in group 1, while to the hilus in group 2. These results suggest that GCs born in early postnatal days numerically dominate adult DG and that there exist sex differences in GC localizations which depend on the time when they were born.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Bromodeoxyuridine,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/prospero-related homeobox 1 protein
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| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
0306-4522
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
7
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| pubmed:volume |
148
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
593-8
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| pubmed:meshHeading |
pubmed-meshheading:17706367-Aging,
pubmed-meshheading:17706367-Animals,
pubmed-meshheading:17706367-Animals, Newborn,
pubmed-meshheading:17706367-Biological Markers,
pubmed-meshheading:17706367-Bromodeoxyuridine,
pubmed-meshheading:17706367-Cell Differentiation,
pubmed-meshheading:17706367-Cell Lineage,
pubmed-meshheading:17706367-Cell Movement,
pubmed-meshheading:17706367-Cell Proliferation,
pubmed-meshheading:17706367-Dentate Gyrus,
pubmed-meshheading:17706367-Female,
pubmed-meshheading:17706367-Homeodomain Proteins,
pubmed-meshheading:17706367-Male,
pubmed-meshheading:17706367-Mice,
pubmed-meshheading:17706367-Mice, Inbred C57BL,
pubmed-meshheading:17706367-Neuronal Plasticity,
pubmed-meshheading:17706367-Neurons,
pubmed-meshheading:17706367-Sex Characteristics,
pubmed-meshheading:17706367-Stem Cells,
pubmed-meshheading:17706367-Tumor Suppressor Proteins
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| pubmed:year |
2007
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| pubmed:articleTitle |
Neonatally born granule cells numerically dominate adult mice dentate gyrus.
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| pubmed:affiliation |
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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