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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2007-9-13
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pubmed:abstractText |
Structure-activity relationship studies centered around 3'-substituted (Z)-5-(2'-(thienylmethylidene))1,2-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5H-chromeno[3,4-f]quinolines are described. A series of highly potent and efficacious selective glucocorticoid receptor modulators were identified with in vitro activity comparable to dexamethasone. In vivo evaluation of these compounds utilizing a 28 day mouse tumor xenograft model demonstrated efficacy equal to dexamethasone in the reduction of tumor volume.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-2623
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pubmed:author |
pubmed-author:AdamsMark EME,
pubmed-author:BissonnetteReid PRP,
pubmed-author:CuervoCatalinaC,
pubmed-author:GharbaouiCatherine JCJ,
pubmed-author:HiguchiRobert IRI,
pubmed-author:HudsonAndrew RAR,
pubmed-author:KallelE AdamEA,
pubmed-author:LamphWilliam WWW,
pubmed-author:LiYongkaiY,
pubmed-author:MaisDale EDE,
pubmed-author:MarschkeKeith BKB,
pubmed-author:MinerJeffrey NJN,
pubmed-author:Negro-VilarAndrésA,
pubmed-author:PhillipsDean PDP,
pubmed-author:RoachSteven LSL,
pubmed-author:RungtaDeepaD,
pubmed-author:ValdezLino JLJ,
pubmed-author:VassarAngieA,
pubmed-author:YenJeanJ,
pubmed-author:ZhiLinL
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4699-709
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pubmed:meshHeading |
pubmed-meshheading:17705362-Animals,
pubmed-meshheading:17705362-Antineoplastic Agents,
pubmed-meshheading:17705362-Benzopyrans,
pubmed-meshheading:17705362-Binding, Competitive,
pubmed-meshheading:17705362-Dexamethasone,
pubmed-meshheading:17705362-Humans,
pubmed-meshheading:17705362-Mice,
pubmed-meshheading:17705362-Models, Molecular,
pubmed-meshheading:17705362-Multiple Myeloma,
pubmed-meshheading:17705362-Quinolines,
pubmed-meshheading:17705362-Receptors, Glucocorticoid,
pubmed-meshheading:17705362-Receptors, Mineralocorticoid,
pubmed-meshheading:17705362-Stereoisomerism,
pubmed-meshheading:17705362-Structure-Activity Relationship,
pubmed-meshheading:17705362-Xenograft Model Antitumor Assays
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pubmed:year |
2007
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pubmed:articleTitle |
Synthesis and characterization of nonsteroidal glucocorticoid receptor modulators for multiple myeloma.
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pubmed:affiliation |
Discovery Research, Ligand Pharmaceuticals, Inc., 10275 Science Center Drive, San Diego, California 92121, USA. ahudson@ligand.com
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pubmed:publicationType |
Journal Article
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