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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-4-16
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pubmed:abstractText |
The pathobiology of alimentary tract (AT) mucositis is complex and there is limited information about the events which lead to the mucosal damage that occurs during cancer treatment. Various transcription factors and proinflammatory cytokines are thought to play important roles in pathogenesis of mucositis. The aim of this study was to determine the expression of nuclear factor-kappaB (NF-kappaB), tumor necrosis factor (TNF) and interleukins-1beta (IL-1beta) and -6 (IL-6) in the AT following the administration of the chemotherapeutic agent irinotecan.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0344-5704
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
33-41
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pubmed:meshHeading |
pubmed-meshheading:17703303-Animals,
pubmed-meshheading:17703303-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:17703303-Camptothecin,
pubmed-meshheading:17703303-Colon,
pubmed-meshheading:17703303-Coloring Agents,
pubmed-meshheading:17703303-Cytokines,
pubmed-meshheading:17703303-Diarrhea,
pubmed-meshheading:17703303-Digestive System,
pubmed-meshheading:17703303-Eosine Yellowish-(YS),
pubmed-meshheading:17703303-Female,
pubmed-meshheading:17703303-Fluorescent Dyes,
pubmed-meshheading:17703303-Gastric Mucosa,
pubmed-meshheading:17703303-Hematoxylin,
pubmed-meshheading:17703303-Immunohistochemistry,
pubmed-meshheading:17703303-Intestinal Mucosa,
pubmed-meshheading:17703303-Jejunum,
pubmed-meshheading:17703303-Mouth Mucosa,
pubmed-meshheading:17703303-Mucositis,
pubmed-meshheading:17703303-NF-kappa B,
pubmed-meshheading:17703303-Rats
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pubmed:year |
2008
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pubmed:articleTitle |
Characterisation of mucosal changes in the alimentary tract following administration of irinotecan: implications for the pathobiology of mucositis.
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pubmed:affiliation |
Oral Pathology, School of Dentistry, Faculty of Health Sciences, The University of Adelaide, North Terrace, SA 5005, Australia. richard.logan@adelaide.edu.au
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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