Linked Life Data

17702663

Source:http://linkedlifedata.com/resource/pubmed/id/17702663

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-9-3
pubmed:abstractText
In this article we evaluated by atomic force microscopy (AFM) the effects of the (novel) tetrabranched antimicrobial peptide SB006 on morphology and mechanical properties of the gram-negative bacterium Pseudomonas aeruginosa. AFM imaging showed that SB006 causes the appearance of significant fragmentariness in the bacterial membrane and a severe volume decrease. Quantitative evaluation of the degree of fragmentariness was allowed by a new ad hoc image analysis procedure. The rigidity of the treated and untreated bacteria was measured through AFM tip nanoindentation measurements, and no differences registered. These results support the membrane interaction hypothesis, according to which SB006 targets the bacterial membranes and disrupts their permeability (allowing the leakage of cytoplasmic material and the subsequent shrinkage), but it does not affect the bacterium wall, which determines its rigidity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1549-9642
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
198-207
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Atomic force microscopy evaluation of the effects of a novel antimicrobial multimeric peptide on Pseudomonas aeruginosa.
pubmed:affiliation
INSTM and Laboratorio di Chimica per le Tecnologie, Università di Brescia, Brescia, Italy.
pubmed:publicationType
Journal Article