Source:http://linkedlifedata.com/resource/pubmed/id/17701054
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2007-11-21
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| pubmed:abstractText |
In the recent past, we have observed a possible role of 10398A and 16189C mtDNA and PGC1alpha p.Thr394Thr (rs2970847) and p.Gly482Ser (rs8192673) variant genotypes providing susceptibility/protection against type 2 diabetes mellitus (T2DM) in two North Indian population groups. These initial observations encouraged us to look at the candidate genes in combination with -866G/A (rs659366) polymorphism in uncoupling protein 2 (UCP2) in a single study of a relatively large sample size, constituted of both the cohorts, to unravel an interesting outcome of an additive interaction in-between the studied genes. In a total of 1,686 individuals (762 cases and 924 controls) belonging to Indo-European linguistic group from North India, a comparison of risk genotype combinations of: UCP2-866GG, mtDNA 10398A and PGC1alpha p.Thr394Thr or p.Gly482Ser against the protective genotypes: UCP2-866XA, mtDNA 10398G and PGC1alpha p.Thr394Thr (nominal P value = 1.75 x 10(-14), Odds ratio, OR = 5.29, 3.40-8.22 at 95% CI) or PGC1alpha p.Gly482Ser (nominal p value = 4.42 x 10(-24), OR = 8.59, 5.53-13.35 at 95% CI), showed a highly significant difference and increased ORs. In a complex disease, it is always encouraging to find an additive interaction of multiple small effects of the studied candidate gene variations.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Mitochondrial,
http://linkedlifedata.com/resource/pubmed/chemical/Heat-Shock Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ion Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Mitochondrial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PPARGC1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/mitochondrial uncoupling protein 2
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| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
1432-1203
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
122
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
535-40
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| pubmed:dateRevised |
2008-6-27
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| pubmed:meshHeading |
pubmed-meshheading:17701054-Adult,
pubmed-meshheading:17701054-Alleles,
pubmed-meshheading:17701054-Amino Acid Substitution,
pubmed-meshheading:17701054-Case-Control Studies,
pubmed-meshheading:17701054-DNA, Mitochondrial,
pubmed-meshheading:17701054-Diabetes Mellitus, Type 2,
pubmed-meshheading:17701054-Female,
pubmed-meshheading:17701054-Gene Frequency,
pubmed-meshheading:17701054-Genetic Predisposition to Disease,
pubmed-meshheading:17701054-Genotype,
pubmed-meshheading:17701054-Heat-Shock Proteins,
pubmed-meshheading:17701054-Humans,
pubmed-meshheading:17701054-India,
pubmed-meshheading:17701054-Ion Channels,
pubmed-meshheading:17701054-Male,
pubmed-meshheading:17701054-Middle Aged,
pubmed-meshheading:17701054-Mitochondrial Proteins,
pubmed-meshheading:17701054-Odds Ratio,
pubmed-meshheading:17701054-Polymorphism, Genetic,
pubmed-meshheading:17701054-Polymorphism, Single Nucleotide,
pubmed-meshheading:17701054-Transcription Factors
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| pubmed:year |
2007
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| pubmed:articleTitle |
Interaction between the UCP2-866G/A, mtDNA 10398G/A and PGC1alpha p.Thr394Thr and p.Gly482Ser polymorphisms in type 2 diabetes susceptibility in North Indian population.
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| pubmed:affiliation |
National Centre of Applied Human Genetics, School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110067, India.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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