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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
2-3
|
|
pubmed:dateCreated |
1992-2-21
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|
pubmed:abstractText |
The changes in glomerular extracellular matrices components in diabetic nephropathy were investigated. Indirect immunofluorescence staining, using polyclonal antibodies to heparan sulfate proteoglycan (HS-PG), laminin, type IV collagen, and fibronectin was carried out on renal specimens obtained by needle biopsy. Immunofluorescence intensity and distribution were observed. HS-PG and laminin decreased in the capillary walls; on the other hand, type IV collagen and fibronectin tended to increase in the mesangial area. HS-PG and laminin decreased in inverse proportion to sclerosis grades and proteinuria. These changes seemed to play an important role in progression of diabetic glomerulosclerosis.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:issn |
0891-6632
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
5
|
|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
186-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1770041-Biopsy, Needle,
pubmed-meshheading:1770041-Collagen,
pubmed-meshheading:1770041-Diabetes Mellitus, Type 1,
pubmed-meshheading:1770041-Diabetes Mellitus, Type 2,
pubmed-meshheading:1770041-Diabetic Nephropathies,
pubmed-meshheading:1770041-Extracellular Matrix,
pubmed-meshheading:1770041-Female,
pubmed-meshheading:1770041-Fibronectins,
pubmed-meshheading:1770041-Fluorescent Antibody Technique,
pubmed-meshheading:1770041-Heparan Sulfate Proteoglycans,
pubmed-meshheading:1770041-Heparitin Sulfate,
pubmed-meshheading:1770041-Humans,
pubmed-meshheading:1770041-Kidney Glomerulus,
pubmed-meshheading:1770041-Laminin,
pubmed-meshheading:1770041-Male,
pubmed-meshheading:1770041-Middle Aged,
pubmed-meshheading:1770041-Proteoglycans
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pubmed:articleTitle |
Changes in glomerular extracellular matrices components in diabetic nephropathy.
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|
pubmed:affiliation |
Third Department of Internal Medicine, Kyushu University Medical School, Okayama, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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