Linked Life Data

17699665

Source:http://linkedlifedata.com/resource/pubmed/id/17699665

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
33
pubmed:dateCreated
2007-8-16
pubmed:abstractText
Repeated stress enhances vulnerability to neural dysfunction that is cumulative over the course of the lifespan. This dysfunction contributes to cognitive deficits observed during aging. In addition, aging is associated with dysregulation of the limbic-hypothalamic-pituitary-adrenal (LHPA) axis, leading to a delayed termination of the stress response. This delay, in turn, increases exposure to glucocorticoids and exacerbates the likelihood of neural damage. Here we asked whether similar effects could emerge at an early age as a result of genetic variations in the level or function of the brain glucocorticoid receptor (GR). We investigated the effect of forebrain-specific overexpression of GR on LHPA axis activity. Transgenic mice with GR overexpression in forebrain (GRov) display normal basal circulating adrenocorticotropic hormone and corticosterone levels. However, young GRov mice exhibit a number of LHPA alterations, including a blunted initial response to acute restraint stress followed by a delayed turn-off of the stress response. This deficit in negative feedback is paradoxical in the face of elevated GR levels, resembles the stress response in aged animals, and continues to worsen as GRov mice age. The neuroendocrine dysregulation in young GRov mice is coupled with a mild cognitive deficit, also consistent with the accelerated aging hypothesis. The molecular basis of this phenotype was examined using microarray analysis of the hippocampus, which revealed a broad downregulation of glutamate receptor signaling in GRov mice. Thus, even in the absence of chronic stress, elevation of GR gene expression can lead to an increased allostatic load and result in an "aging-like" phenotype in young animals.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8836-44
pubmed:dateRevised
2011-8-1
pubmed:meshHeading
pubmed-meshheading:17699665-Adrenocorticotropic Hormone, pubmed-meshheading:17699665-Aging, pubmed-meshheading:17699665-Analysis of Variance, pubmed-meshheading:17699665-Animals, pubmed-meshheading:17699665-Behavior, Animal, pubmed-meshheading:17699665-Cognition Disorders, pubmed-meshheading:17699665-Corticosterone, pubmed-meshheading:17699665-Dexamethasone, pubmed-meshheading:17699665-Gene Expression Regulation, pubmed-meshheading:17699665-Maze Learning, pubmed-meshheading:17699665-Mice, pubmed-meshheading:17699665-Mice, Inbred C57BL, pubmed-meshheading:17699665-Mice, Transgenic, pubmed-meshheading:17699665-Microarray Analysis, pubmed-meshheading:17699665-Neurosecretory Systems, pubmed-meshheading:17699665-Oligonucleotide Array Sequence Analysis, pubmed-meshheading:17699665-Prosencephalon, pubmed-meshheading:17699665-Receptors, Glucocorticoid, pubmed-meshheading:17699665-Receptors, Glutamate, pubmed-meshheading:17699665-Restraint, Physical, pubmed-meshheading:17699665-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:17699665-Stress, Psychological
pubmed:year
2007
pubmed:articleTitle
Overexpressing the glucocorticoid receptor in forebrain causes an aging-like neuroendocrine phenotype and mild cognitive dysfunction.
pubmed:affiliation
Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109, USA. qweis@umich.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural