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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-9-3
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pubmed:abstractText |
Familial hemophagocytic lymphohistiocytosis is a genetically determined condition that is characterized by unremitting CD8 T lymphocyte and macrophage activation and leads to death in the absence of therapy. On the basis of the immunologic pathophysiology of familial hemophagocytic lymphohistiocytosis, we propose a therapy with a combination of antithymocyte globulins with corticosteroids, cyclosporin A, and intrathecal injections of methotrexate.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1098-4275
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
120
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e622-8
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pubmed:meshHeading |
pubmed-meshheading:17698967-Adrenal Cortex Hormones,
pubmed-meshheading:17698967-Antilymphocyte Serum,
pubmed-meshheading:17698967-Child,
pubmed-meshheading:17698967-Child, Preschool,
pubmed-meshheading:17698967-Cyclosporine,
pubmed-meshheading:17698967-Drug Therapy, Combination,
pubmed-meshheading:17698967-Female,
pubmed-meshheading:17698967-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:17698967-Humans,
pubmed-meshheading:17698967-Immunosuppressive Agents,
pubmed-meshheading:17698967-Immunotherapy,
pubmed-meshheading:17698967-Infection,
pubmed-meshheading:17698967-Injections, Spinal,
pubmed-meshheading:17698967-Lymphohistiocytosis, Hemophagocytic,
pubmed-meshheading:17698967-Lymphoproliferative Disorders,
pubmed-meshheading:17698967-Male,
pubmed-meshheading:17698967-Methotrexate,
pubmed-meshheading:17698967-Methylprednisolone,
pubmed-meshheading:17698967-Recurrence,
pubmed-meshheading:17698967-Retrospective Studies,
pubmed-meshheading:17698967-Treatment Outcome
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pubmed:year |
2007
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pubmed:articleTitle |
Immunotherapy of familial hemophagocytic lymphohistiocytosis with antithymocyte globulins: a single-center retrospective report of 38 patients.
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pubmed:affiliation |
Unité d'Immunologie et Hématologie Pédiatrique, Hôpital Necker-Enfants Malades, 149 rue de Sèvres, 75015 Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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