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rdf:type |
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lifeskim:mentions |
umls-concept:C0032285,
umls-concept:C0079189,
umls-concept:C0162340,
umls-concept:C0243026,
umls-concept:C0314603,
umls-concept:C0333348,
umls-concept:C0871261,
umls-concept:C1274040,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2603343,
umls-concept:C2745888,
umls-concept:C2911692
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|
pubmed:issue |
15
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pubmed:dateCreated |
2007-8-16
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pubmed:abstractText |
Severe sepsis is common and frequently fatal, and community-acquired pneumonia (CAP) is the leading cause. Although severe sepsis is often attributed to uncontrolled and unbalanced inflammation, evidence from humans with infection syndromes across the breadth of disease is lacking. In this study we describe the systemic cytokine response to pneumonia and determine if specific patterns, including the balance of proinflammatory and anti-inflammatory markers, are associated with severe sepsis and death.
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pubmed:grant |
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pubmed:commentsCorrections |
|
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:issn |
0003-9926
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pubmed:author |
pubmed-author:AngusDerek CDC,
pubmed-author:BrownD RossDR,
pubmed-author:DeludeRussell LRL,
pubmed-author:FineJonathanJ,
pubmed-author:FinkMitchell PMP,
pubmed-author:GenIMS Investigators,
pubmed-author:KellumJohn AJA,
pubmed-author:KongLanL,
pubmed-author:PinskyMichael RMR,
pubmed-author:WeissfeldLisa ALA,
pubmed-author:YealyDonald MDM
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|
pubmed:issnType |
Print
|
|
pubmed:volume |
167
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
1655-63
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pubmed:dateRevised |
2008-8-6
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pubmed:meshHeading |
pubmed-meshheading:17698689-Aged,
pubmed-meshheading:17698689-Cohort Studies,
pubmed-meshheading:17698689-Community-Acquired Infections,
pubmed-meshheading:17698689-Female,
pubmed-meshheading:17698689-Humans,
pubmed-meshheading:17698689-Inflammation,
pubmed-meshheading:17698689-Interleukin-10,
pubmed-meshheading:17698689-Interleukin-6,
pubmed-meshheading:17698689-Male,
pubmed-meshheading:17698689-Pneumonia, Bacterial,
pubmed-meshheading:17698689-Sepsis,
pubmed-meshheading:17698689-Severity of Illness Index,
pubmed-meshheading:17698689-Tumor Necrosis Factor-alpha
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pubmed:articleTitle |
Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study.
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pubmed:affiliation |
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, 604 Scaife Hall, 3550 Terrace St, Pittsburgh, PA15261, USA.
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pubmed:publicationType |
Journal Article,
Multicenter Study,
Research Support, N.I.H., Extramural
|
