|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0012197,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0112154,
umls-concept:C0175677,
umls-concept:C0205070,
umls-concept:C0205263,
umls-concept:C0220894,
umls-concept:C0405581,
umls-concept:C0522498,
umls-concept:C1280500,
umls-concept:C1456501
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2007-9-10
|
|
pubmed:abstractText |
To investigate the preventive effects of d-psicose, one of rare ketohexoses, on di-(2-ethylhexyl) phthalate (DEHP)-induced testicular injury, prepubertal male Sprague-Dawley rats were exposed to DEHP via their diet or orally, while under treatment with d-psicose. The rats given a diet-containing 1% DEHP alone for 7-14 days showed severe testicular atrophy accompanied by aspermatogenesis. On the other hand, those given the diet plus 2% but not 1% d-psicose-supplemented water for 14 days did not develop testicular atrophy, and exhibited an almost complete spermatogenesis. There was no significant difference in plasma mono-(2-ethylhexyl) phthalate (MEHP) levels between the d-psicose-free and d-psicose-treated groups. The testicular malondialdehyde (MDA) level after a single oral administration of 2g/kg of DEHP showed a similar pattern of increase to the plasma MEHP level and peaked in 24h suggesting a close and dose-dependent relation between plasma MEHP and testicular reactive oxygen species (ROS) levels. Pretreatment with d-psicose at a concentration of 2% and 4% resulted in an almost complete but not absolute suppression of testicular MDA production among rats administered 2g/kg of DEHP. The microarray analysis showed the induction of oxidative stress related genes including the thioredoxin, glutathione peroxidase 1 and 2, glutaredoixn 1 after 24h of the DEHP treatment in the testis. These results show that d-psicose prevents DEHP-induced testicular injury by suppressing the generation of ROS in the rat testis. This effect may be due to the direct scavenging by d-psicose of ROS generated in the testis.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Diethylhexyl Phthalate,
http://linkedlifedata.com/resource/pubmed/chemical/Free Radical Scavengers,
http://linkedlifedata.com/resource/pubmed/chemical/Fructose,
http://linkedlifedata.com/resource/pubmed/chemical/Glrx2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Glutaredoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Peroxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Malondialdehyde,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidoreductases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Thioredoxins,
http://linkedlifedata.com/resource/pubmed/chemical/glutathione peroxidase GPX1,
http://linkedlifedata.com/resource/pubmed/chemical/mono-(2-ethylhexyl)phthalate,
http://linkedlifedata.com/resource/pubmed/chemical/psicose
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0378-4274
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
10
|
|
pubmed:volume |
173
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
107-17
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:17698303-Animals,
pubmed-meshheading:17698303-Atrophy,
pubmed-meshheading:17698303-Diethylhexyl Phthalate,
pubmed-meshheading:17698303-Dose-Response Relationship, Drug,
pubmed-meshheading:17698303-Free Radical Scavengers,
pubmed-meshheading:17698303-Fructose,
pubmed-meshheading:17698303-Gene Expression,
pubmed-meshheading:17698303-Glutaredoxins,
pubmed-meshheading:17698303-Glutathione Peroxidase,
pubmed-meshheading:17698303-Male,
pubmed-meshheading:17698303-Malondialdehyde,
pubmed-meshheading:17698303-Oxidative Stress,
pubmed-meshheading:17698303-Oxidoreductases,
pubmed-meshheading:17698303-RNA,
pubmed-meshheading:17698303-Rats,
pubmed-meshheading:17698303-Rats, Sprague-Dawley,
pubmed-meshheading:17698303-Reactive Oxygen Species,
pubmed-meshheading:17698303-Spermatogenesis,
pubmed-meshheading:17698303-Testicular Diseases,
pubmed-meshheading:17698303-Testis,
pubmed-meshheading:17698303-Thioredoxins,
pubmed-meshheading:17698303-Time Factors
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Preventive effect of D-psicose, one of rare ketohexoses, on di-(2-ethylhexyl) phthalate (DEHP)-induced testicular injury in rat.
|
|
pubmed:affiliation |
Department of Hygiene and Public Health, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kagawa 761-0793, Japan. suna@med.kagawa-u.ac.jp
|
|
pubmed:publicationType |
Journal Article
|
