17697961

Source:http://linkedlifedata.com/resource/pubmed/id/17697961

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0023487, umls-concept:C0206153, umls-concept:C0282443, umls-concept:C1552617, umls-concept:C1880156, umls-concept:C2323499
pubmed:issue	9
pubmed:dateCreated	2007-8-16
pubmed:abstractText	The past three decades have brought major therapeutic advances in the management of acute promyelocytic leukemia. The current state-of-the-art induction treatment with all-trans retinoic acid in combination with anthracycline-based chemotherapy results in long-lasting remissions and cure in up to 70% of newly diagnosed patients. Unfortunately, treatment failure still occurs in one-third of patients. When disease relapses, patients can achieve subsequent remissions with arsenic trioxide, all-trans retinoic acid with or without chemotherapy, or other therapies. Patients achieving molecular remissions after salvage therapy are generally considered candidates for high-dose chemotherapy and autologous hematopoietic cell transplantation as a postconsolidation strategy. On the other hand, patients with evidence of persistent hematologic or molecular disease after salvage therapy could be offered allogeneic hematopoietic transplantation if a suitable HLA-donor is identified and the patient's overall performance and clinical condition are permissible. We hereby provide a comprehensive review and analysis of published clinical trials that evaluate the role of hematopoietic cell transplantation across different stages of acute promyelocytic leukemia.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9600628
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	1083-8791
pubmed:author	pubmed-author:Abou MouradYasser RYR, pubmed-author:FernandezHugo FHF, pubmed-author:Kharfan-DabajaMohamed AMA, pubmed-author:PasquiniMarcelo CMC, pubmed-author:SantosEdgardo SES
pubmed:issnType	Print
pubmed:volume	13
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	997-1004
pubmed:meshHeading	pubmed-meshheading:17697961-Hematopoietic Stem Cell Transplantation, pubmed-meshheading:17697961-Humans, pubmed-meshheading:17697961-Leukemia, Promyelocytic, Acute, pubmed-meshheading:17697961-Salvage Therapy, pubmed-meshheading:17697961-Treatment Failure
pubmed:year	2007
pubmed:articleTitle	Hematopoietic cell transplantation in acute promyelocytic leukemia: a comprehensive review.
pubmed:affiliation	Department of Interdisciplinary Oncology, H. Lee Moffitt Cancer Center and Research Institute and University of South Florida, Tampa 33612, USA, and Division of Hematology, Vancouver General Hospital, British Columbia, Canada. Kharfama@moffitt.usf.edu
pubmed:publicationType	Journal Article, Review