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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-12-21
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pubmed:abstractText |
We describe four children with Dravet syndrome treated with the combination of valproic acid (VPA) and topiramate (TPM) who developed transient liver toxicity. The time-interval between fever, administration of acetaminophen, epileptic status and liver enzyme disturbances in our four cases suggests that accumulation of toxic acetaminophen-metabolites is possibly responsible for liver toxicity. If acetaminophen and its metabolites cause those liver problems in children treated with the combination of VPA and TPM, the advice to use acetaminophen for treating fever in children using this combination, should be changed. Only future clinical observations and research can solve this clinical dilemma.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetaminophen,
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics, Non-Narcotic,
http://linkedlifedata.com/resource/pubmed/chemical/Anticonvulsants,
http://linkedlifedata.com/resource/pubmed/chemical/Enzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Fructose,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Valproic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/sodium channel, voltage-gated...,
http://linkedlifedata.com/resource/pubmed/chemical/topiramate
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1059-1311
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
92-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17697789-Acetaminophen,
pubmed-meshheading:17697789-Analgesics, Non-Narcotic,
pubmed-meshheading:17697789-Anticonvulsants,
pubmed-meshheading:17697789-Developmental Disabilities,
pubmed-meshheading:17697789-Drug Therapy, Combination,
pubmed-meshheading:17697789-Drug-Induced Liver Injury,
pubmed-meshheading:17697789-Enzymes,
pubmed-meshheading:17697789-Female,
pubmed-meshheading:17697789-Fructose,
pubmed-meshheading:17697789-Humans,
pubmed-meshheading:17697789-Infant,
pubmed-meshheading:17697789-Influenza, Human,
pubmed-meshheading:17697789-Liver Function Tests,
pubmed-meshheading:17697789-Male,
pubmed-meshheading:17697789-Myoclonic Epilepsy, Juvenile,
pubmed-meshheading:17697789-Nerve Tissue Proteins,
pubmed-meshheading:17697789-Sodium Channels,
pubmed-meshheading:17697789-Syndrome,
pubmed-meshheading:17697789-Valproic Acid
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pubmed:year |
2008
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pubmed:articleTitle |
Acute hepatic injury in four children with Dravet syndrome: valproic acid, topiramate or acetaminophen?
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pubmed:affiliation |
Department of Neurology, University Hospital Maastricht, Maastricht, The Netherlands. jnic@sneu.azm.nl
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pubmed:publicationType |
Journal Article,
Case Reports
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