|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2008-5-16
|
|
pubmed:abstractText |
During 2003, a cluster of initially unexplained pneumonia cases (two fatal) occurred in patients aged <50 years in a British city. Routine culture tests were inconclusive, however, pneumococcal infection was suspected and the putative outbreak was investigated using non-culture methods. Clinical samples from ten patients were tested by pneumococcal polymerase chain reaction (PCR) and multi-locus sequence typing (MLST), or Binax NOW pneumococcal urine antigen test and serotype-specific enzyme-linked immunosorbent assay (ELISA). Lung samples from the deceased patients were PCR positive and yielded different MLST types. Two patients in one family group were serotype 1 pneumococcal antigen positive. Two further patients were serotype 1 antigen positive, and one serotype 4 positive. Two antigen-positive cases were also serum PCR positive. Non-culture methods confirmed the disease aetiology in six cases. Serotype and MLST results showed no single outbreak, but a family cluster of cases in a high background of pneumococcal pneumonia, providing important epidemiological data that would not otherwise have been available.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17697442-11731965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17697442-12517914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17697442-12843005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17697442-14605125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17697442-14708267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17697442-14970243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17697442-1576274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17697442-15815045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17697442-16207950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17697442-6309001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17697442-9718833
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0950-2688
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
136
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
922-7
|
|
pubmed:dateRevised |
2010-9-15
|
|
pubmed:meshHeading |
pubmed-meshheading:17697442-Adolescent,
pubmed-meshheading:17697442-Adult,
pubmed-meshheading:17697442-Antigens, Bacterial,
pubmed-meshheading:17697442-Child,
pubmed-meshheading:17697442-Child, Preschool,
pubmed-meshheading:17697442-DNA, Bacterial,
pubmed-meshheading:17697442-Disease Outbreaks,
pubmed-meshheading:17697442-Female,
pubmed-meshheading:17697442-Great Britain,
pubmed-meshheading:17697442-Humans,
pubmed-meshheading:17697442-Immunoassay,
pubmed-meshheading:17697442-Lung,
pubmed-meshheading:17697442-Male,
pubmed-meshheading:17697442-Middle Aged,
pubmed-meshheading:17697442-Molecular Diagnostic Techniques,
pubmed-meshheading:17697442-Pneumonia, Pneumococcal,
pubmed-meshheading:17697442-Polymerase Chain Reaction,
pubmed-meshheading:17697442-Sequence Analysis, DNA,
pubmed-meshheading:17697442-Serotyping,
pubmed-meshheading:17697442-Serum,
pubmed-meshheading:17697442-Streptococcus pneumoniae,
pubmed-meshheading:17697442-Urine
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
The clinical and public health value of non-culture methods in the investigation of a cluster of unexplained pneumonia cases.
|
|
pubmed:affiliation |
Respiratory and Systemic Infection Laboratory, Health Protection Agency, Centre for Infections, London, UK. carmen.sheppard@hpa.org.uk
|
|
pubmed:publicationType |
Journal Article
|
