|
rdf:type |
|
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lifeskim:mentions |
umls-concept:C0007137,
umls-concept:C0023688,
umls-concept:C0025932,
umls-concept:C0086418,
umls-concept:C0205195,
umls-concept:C0333516,
umls-concept:C0442027,
umls-concept:C0450442,
umls-concept:C0520484,
umls-concept:C0596581,
umls-concept:C0598934,
umls-concept:C0879262,
umls-concept:C1280500
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|
pubmed:issue |
4B
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|
pubmed:dateCreated |
2007-8-15
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|
pubmed:abstractText |
Chemotherapy has shown little antitumor activity against advanced oral squamous cell carcinoma (OSCC) patients. Therefore, there is an urgent need to develop more effective therapeutic methods for patients with advanced OSCC. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor ligand family that selectively induces apoptosis of cancer cells. S-1 is a new oral antineoplastic agent that can induce apoptosis in various types of cancer cells, including OSCC. Hence, combined treatment of cancer cells with TRAIL and S-1 might exert dramatic antitumor effects on OSCC cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:issn |
0250-7005
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2365-75
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pubmed:meshHeading |
pubmed-meshheading:17695527-Animals,
pubmed-meshheading:17695527-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:17695527-Apoptosis,
pubmed-meshheading:17695527-Body Weight,
pubmed-meshheading:17695527-Carcinoma, Squamous Cell,
pubmed-meshheading:17695527-Cell Growth Processes,
pubmed-meshheading:17695527-Cell Line, Tumor,
pubmed-meshheading:17695527-Dihydrouracil Dehydrogenase (NADP),
pubmed-meshheading:17695527-Drug Combinations,
pubmed-meshheading:17695527-Drug Synergism,
pubmed-meshheading:17695527-Female,
pubmed-meshheading:17695527-Gene Expression,
pubmed-meshheading:17695527-Humans,
pubmed-meshheading:17695527-Mice,
pubmed-meshheading:17695527-Mice, Nude,
pubmed-meshheading:17695527-Orotate Phosphoribosyltransferase,
pubmed-meshheading:17695527-Oxonic Acid,
pubmed-meshheading:17695527-RNA, Messenger,
pubmed-meshheading:17695527-TNF-Related Apoptosis-Inducing Ligand,
pubmed-meshheading:17695527-Tegafur,
pubmed-meshheading:17695527-Thymidylate Synthase,
pubmed-meshheading:17695527-Xenograft Model Antitumor Assays
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pubmed:articleTitle |
Effects of tumor necrosis factor-related apoptosis-inducing ligand alone and in combination with fluoropyrimidine anticancer agent, S-1, on tumor growth of human oral squamous cell carcinoma xenografts in nude mice.
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pubmed:affiliation |
Department of Therapeutic Regulation for Oral Tumors, Institute of Health Bioscience, University of Tokushima Graduate School, Tokushima, Japan.
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pubmed:publicationType |
Journal Article
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