Colchicine has been used to treat gout for centuries. However, owing to its toxicity it displays a variety of side effects. The replacement of colchicine by less toxic but still active derivatives would solve this drawback.
Institute of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry Palacký University Olomouc, Hnevotínská 3, 77515 OLOMOUC, Czech Republic. moulin@email.cz