pubmed-article:17688198 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:17688198 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
pubmed-article:17688198 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
pubmed-article:17688198 | lifeskim:mentions | umls-concept:C1415750 | lld:lifeskim |
pubmed-article:17688198 | pubmed:issue | 2 | lld:pubmed |
pubmed-article:17688198 | pubmed:dateCreated | 2007-8-10 | lld:pubmed |
pubmed-article:17688198 | pubmed:abstractText | Previous work in our laboratory demonstrated the existence of an association between heat shock transcription factor 2 (HSF2) and the serine/threonine phosphatase 2A, which is mediated by interaction between HSF2 and the A subunit (also called PR65) of this protein phosphatase. In light of the importance of HSF2-PP2A association for HSF2 cellular function, in this study, we have sought to dissect the sequences within HSF2 that are important for interaction with the A subunit of PP2A. The results of these experiments indicate that the HSF2 region comprising amino acids 343-363 is important for A subunit interaction. This region includes part of the C-terminal leucine zipper motif of HSF2 called heptad repeat C (HR-C). The results of transfection/immunoprecipitation experiments also show that deletion of the 6 amino acids from 343 to 348 from HSF2 (HSF2 (delta343-348)), is sufficient to prevent HSF2 from interacting with PP2A. These data provide insight into a new functional domain of HSF2, the PP2A A subunit-interacting region. | lld:pubmed |
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pubmed-article:17688198 | pubmed:language | eng | lld:pubmed |
pubmed-article:17688198 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17688198 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:17688198 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:17688198 | pubmed:issn | 1355-8145 | lld:pubmed |
pubmed-article:17688198 | pubmed:author | pubmed-author:SargeKevin... | lld:pubmed |
pubmed-article:17688198 | pubmed:author | pubmed-author:HongYilingY | lld:pubmed |
pubmed-article:17688198 | pubmed:author | pubmed-author:XingHongyanH | lld:pubmed |
pubmed-article:17688198 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:17688198 | pubmed:volume | 12 | lld:pubmed |
pubmed-article:17688198 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:17688198 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:17688198 | pubmed:pagination | 192-7 | lld:pubmed |
pubmed-article:17688198 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:17688198 | pubmed:meshHeading | pubmed-meshheading:17688198... | lld:pubmed |
pubmed-article:17688198 | pubmed:year | 2007 | lld:pubmed |
pubmed-article:17688198 | pubmed:articleTitle | Identification of the PP2A-interacting region of heat shock transcription factor 2. | lld:pubmed |
pubmed-article:17688198 | pubmed:affiliation | Department of Molecular and Cellular Biochemistry, University of Kentucky, 741 S Limestone Streeet, Lexington, KY 40536, USA. | lld:pubmed |
pubmed-article:17688198 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:17688198 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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