Linked Life Data

17686601

Source:http://linkedlifedata.com/resource/pubmed/id/17686601

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2007-11-12
pubmed:abstractText
Aluminium (Al), a neurotoxic compound, has been investigated in a large number of studies both in vivo and in vitro. In this study, we investigated the effect in vivo of long-term exposure to Al on NTPDase (nucleoside triphosphate diphosphohydrolase) and 5'-nucleotidase activities in the synaptosomes (obtained from the cerebral cortex and hippocampus) and platelets of rats. Here, we investigated a possible role of platelets as peripheral markers in rats. Rats were loaded by gavage with AlCl(3) 50 mg/(kg day), 5 days per week, totalizing 60 administrations. The animals were divided into four groups: (1) control (C), (2) 50 mg/kg of citrate solution (Ci), (3) 50 mg/kg of Al plus citrate (Al+Ci) solution and (4) 50 mg/kg of Al (Al). ATP hydrolysis was increased in the synaptosomes from the cerebral cortex by 42.9% for Al+Ci and 39.39% for Al, when compared to their respective control (p<0.05). ADP hydrolysis was increased by 13.15% for both Al and Al+Ci, and AMP hydrolysis increased by 32.7% for Al and 27.25% for Al+Ci (p<0.05). In hippocampal synaptosomes, the hydrolysis of ATP, ADP and AMP, was increased by 58.5%, 28.5% and 25.92%, respectively, for Al (p<0.05) and 36.7%, 22.5% and 37.64% for Al+Ci, both when compared to their respective controls. ATP, ADP and AMP hydrolysis, in platelets, was increased by 172.3%, 188.52% and 92.1%, respectively in Al+Ci, and 317.9%, 342.8% and 177.9%, respectively, for Al, when compared to their respective controls (p<0.05). Together, these results indicate that Al increases NTPDase and 5'-nucleotidase activities, in synaptosomal fractions and platelets. Thus, we suggest that platelets could be sensitive peripheral markers of Al toxicity of the central nervous system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0736-5748
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
381-6
pubmed:meshHeading
pubmed-meshheading:17686601-5'-Nucleotidase, pubmed-meshheading:17686601-Adenosine Triphosphate, pubmed-meshheading:17686601-Aluminum, pubmed-meshheading:17686601-Aluminum Compounds, pubmed-meshheading:17686601-Animals, pubmed-meshheading:17686601-Antigens, CD, pubmed-meshheading:17686601-Apyrase, pubmed-meshheading:17686601-Biological Markers, pubmed-meshheading:17686601-Blood Platelets, pubmed-meshheading:17686601-Brain, pubmed-meshheading:17686601-Cerebral Cortex, pubmed-meshheading:17686601-Chlorides, pubmed-meshheading:17686601-Citrates, pubmed-meshheading:17686601-Hydrolysis, pubmed-meshheading:17686601-Male, pubmed-meshheading:17686601-Presynaptic Terminals, pubmed-meshheading:17686601-Rats, pubmed-meshheading:17686601-Rats, Wistar, pubmed-meshheading:17686601-Synaptic Transmission, pubmed-meshheading:17686601-Synaptosomes
pubmed:year
2007
pubmed:articleTitle
The effect of aluminium on NTPDase and 5'-nucleotidase activities from rat synaptosomes and platelets.
pubmed:affiliation
Programa de Pós-Graduação em Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Av Roraima, 97105-900, Santa Maria, RS, Brazil.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't