| pubmed-article:1768567 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1768567 | lifeskim:mentions | umls-concept:C0442027 | lld:lifeskim |
| pubmed-article:1768567 | lifeskim:mentions | umls-concept:C0019469 | lld:lifeskim |
| pubmed-article:1768567 | lifeskim:mentions | umls-concept:C0035608 | lld:lifeskim |
| pubmed-article:1768567 | lifeskim:mentions | umls-concept:C1314792 | lld:lifeskim |
| pubmed-article:1768567 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:1768567 | lifeskim:mentions | umls-concept:C0022203 | lld:lifeskim |
| pubmed-article:1768567 | lifeskim:mentions | umls-concept:C0449297 | lld:lifeskim |
| pubmed-article:1768567 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1768567 | pubmed:dateCreated | 1992-2-27 | lld:pubmed |
| pubmed-article:1768567 | pubmed:abstractText | 1. The disposition of hexobarbitone enantiomers before and after rifampicin treatment (600 mg daily for 14 days) was investigated in six young (29 +/- 3 years old) and six elderly (71 +/- 4 years old) healthy male volunteers. Hexobarbitone was given as a single 500 mg oral dose of the racemate. 2. The mean (+/- s.d.) oral clearance of S-(+) hexobarbitone was 1.9 +/- 0.3 and 1.8 +/- 0.2 ml min-1 kg-1, respectively, in young and elderly subjects and increased approximately six fold following 14 days of rifampicin treatment in both young (to 11.9 +/- 2.2 ml min-1 kg-1) and elderly (to 10.7 +/- 2.8 ml min-1 kg-1) subjects. 3. In contrast, rifampicin treatment produced a larger and a differential increase in the oral clearance of R-(-) hexobarbitone in young and elderly subjects; an 89 fold change in the young (15.6 +/- 16.4 to 1146.7 +/- 1478.0 ml min-1 kg-1) and a 19 fold change (10.3 +/- 3.0 to 199.9 +/- 98.1 ml min-1 kg-1) in the elderly. | lld:pubmed |
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| pubmed-article:1768567 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1768567 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1768567 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1768567 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1768567 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1768567 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1768567 | pubmed:issn | 0306-5251 | lld:pubmed |
| pubmed-article:1768567 | pubmed:author | pubmed-author:SmithD ADA | lld:pubmed |
| pubmed-article:1768567 | pubmed:author | pubmed-author:BlouinR ARA | lld:pubmed |
| pubmed-article:1768567 | pubmed:author | pubmed-author:ChandlerM HMH | lld:pubmed |
| pubmed-article:1768567 | pubmed:author | pubmed-author:WedlundP JPJ | lld:pubmed |
| pubmed-article:1768567 | pubmed:author | pubmed-author:ShedlofskyS... | lld:pubmed |
| pubmed-article:1768567 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1768567 | pubmed:volume | 32 | lld:pubmed |
| pubmed-article:1768567 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1768567 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1768567 | pubmed:pagination | 735-9 | lld:pubmed |
| pubmed-article:1768567 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1768567 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1768567 | pubmed:articleTitle | Age-dependent stereoselective increase in the oral clearance of hexobarbitone isomers caused by rifampicin. | lld:pubmed |
| pubmed-article:1768567 | pubmed:affiliation | College of Pharmacy, University of Kentucky, Lexington 40536-0082. | lld:pubmed |
| pubmed-article:1768567 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1768567 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1768567 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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