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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1992-2-27
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pubmed:abstractText |
1. The disposition of hexobarbitone enantiomers before and after rifampicin treatment (600 mg daily for 14 days) was investigated in six young (29 +/- 3 years old) and six elderly (71 +/- 4 years old) healthy male volunteers. Hexobarbitone was given as a single 500 mg oral dose of the racemate. 2. The mean (+/- s.d.) oral clearance of S-(+) hexobarbitone was 1.9 +/- 0.3 and 1.8 +/- 0.2 ml min-1 kg-1, respectively, in young and elderly subjects and increased approximately six fold following 14 days of rifampicin treatment in both young (to 11.9 +/- 2.2 ml min-1 kg-1) and elderly (to 10.7 +/- 2.8 ml min-1 kg-1) subjects. 3. In contrast, rifampicin treatment produced a larger and a differential increase in the oral clearance of R-(-) hexobarbitone in young and elderly subjects; an 89 fold change in the young (15.6 +/- 16.4 to 1146.7 +/- 1478.0 ml min-1 kg-1) and a 19 fold change (10.3 +/- 3.0 to 199.9 +/- 98.1 ml min-1 kg-1) in the elderly.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-1127574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-1164824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-1164825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-1233266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-2223426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-2311333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-2328190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-2590599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-3050903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-3064184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-3123247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-3356087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-3385644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-3509435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-3518987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-3667803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-4148519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-4389286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-4396729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-445957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-4714228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-4809266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-5111462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-6092093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-6138236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-6380442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-665427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-6733008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-7057383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-849678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1768567-948025
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0306-5251
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
735-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1768567-Administration, Oral,
pubmed-meshheading:1768567-Adult,
pubmed-meshheading:1768567-Aged,
pubmed-meshheading:1768567-Aging,
pubmed-meshheading:1768567-Chromatography, High Pressure Liquid,
pubmed-meshheading:1768567-Drug Interactions,
pubmed-meshheading:1768567-Hexobarbital,
pubmed-meshheading:1768567-Humans,
pubmed-meshheading:1768567-Male,
pubmed-meshheading:1768567-Metabolic Clearance Rate,
pubmed-meshheading:1768567-Rifampin,
pubmed-meshheading:1768567-Stereoisomerism
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pubmed:year |
1991
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pubmed:articleTitle |
Age-dependent stereoselective increase in the oral clearance of hexobarbitone isomers caused by rifampicin.
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pubmed:affiliation |
College of Pharmacy, University of Kentucky, Lexington 40536-0082.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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