Linked Life Data

17684131

Source:http://linkedlifedata.com/resource/pubmed/id/17684131

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2007-8-8
pubmed:abstractText
Traditionally, case-control studies of sexually transmitted infections and prostate cancer have focused on gonorrhea and syphilis, with overall positive associations. More recently, researchers have begun to expand their focus to include additional sexually transmitted infections, such as Chlamydia trachomatis, human papillomavirus (HPV), and human herpesvirus type 8 (HHV-8) infections. Continuing this investigation, we examined each of these infections in relation to incident prostate cancer in a nested case-control study within the Health Professionals Follow-up Study. Prostate cancer cases were men diagnosed with prostate cancer between the date of blood draw (1993-1995) and 2000 (n = 691). Controls were men free of cancer and alive at the time of case diagnosis who had had at least one prostate-specific antigen test between the date of blood draw and case diagnosis. One control was individually matched to each case by age; year, time of day, and season of blood draw; and prostate-specific antigen screening history before blood draw (n = 691). C. trachomatis and HPV-16, HPV-18, and HPV-33 antibody serostatus were assessed by enzyme-based immunoassays and HHV-8 antibody serostatus was assessed by an immunofluorescence assay. No associations were observed between C. trachomatis [odds ratio (OR), 1.13; 95% confidence interval (95% CI), 0.65-1.96], HPV-16 (OR, 0.83; 95% CI, 0.57-1.23), HPV-18 (OR, 1.04; 95% CI, 0.66-1.64), and HPV-33 (OR, 1.14; 95% CI, 0.76-1.72) antibody seropositivity and prostate cancer. A significant inverse association was observed between HHV-8 antibody seropositivity and prostate cancer (OR, 0.70; 95% CI, 0.52-0.95). As this study is the first, to our knowledge, to observe such an inverse association, similar additional studies are warranted.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1055-9965
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1573-80
pubmed:dateRevised
2011-2-7
pubmed:meshHeading
pubmed-meshheading:17684131-Adult, pubmed-meshheading:17684131-Age Factors, pubmed-meshheading:17684131-Aged, pubmed-meshheading:17684131-Anti-Inflammatory Agents, Non-Steroidal, pubmed-meshheading:17684131-Antibodies, Bacterial, pubmed-meshheading:17684131-Antibodies, Viral, pubmed-meshheading:17684131-Aspirin, pubmed-meshheading:17684131-Case-Control Studies, pubmed-meshheading:17684131-Chlamydia Infections, pubmed-meshheading:17684131-Chlamydia trachomatis, pubmed-meshheading:17684131-Herpesviridae Infections, pubmed-meshheading:17684131-Herpesvirus 8, Human, pubmed-meshheading:17684131-Human papillomavirus 16, pubmed-meshheading:17684131-Human papillomavirus 18, pubmed-meshheading:17684131-Humans, pubmed-meshheading:17684131-Immunoglobulin G, pubmed-meshheading:17684131-Male, pubmed-meshheading:17684131-Middle Aged, pubmed-meshheading:17684131-Papillomavirus Infections, pubmed-meshheading:17684131-Prospective Studies, pubmed-meshheading:17684131-Prostate-Specific Antigen, pubmed-meshheading:17684131-Prostatic Neoplasms
pubmed:year
2007
pubmed:articleTitle
Plasma antibodies against Chlamydia trachomatis, human papillomavirus, and human herpesvirus type 8 in relation to prostate cancer: a prospective study.
pubmed:affiliation
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Room E6132-A, 615 North Wolfe Street, Baltimore, MD 21205, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural