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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2007-9-18
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pubmed:abstractText |
A series of cinnamyl compounds related to 2'-hydroxycinnamaldehyde were synthesized and their antitumor effects against human cancer cells evaluated. Hydroxylamine derivative 6 inhibited the growth of human cancer cells and human colon tumor xenograft in nude mice. Its antitumor effects belong to the induction of apoptosis and arresting cell cycle at G(2)/M phase, which is confirmed by detection of apoptosis markers and cell cycle analysis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5423-7
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pubmed:meshHeading |
pubmed-meshheading:17683933-Animals,
pubmed-meshheading:17683933-Antineoplastic Agents,
pubmed-meshheading:17683933-Apoptosis,
pubmed-meshheading:17683933-Caspase 3,
pubmed-meshheading:17683933-Cell Cycle,
pubmed-meshheading:17683933-Cell Division,
pubmed-meshheading:17683933-Cell Line, Tumor,
pubmed-meshheading:17683933-Cinnamates,
pubmed-meshheading:17683933-Cinnamomum,
pubmed-meshheading:17683933-Dose-Response Relationship, Drug,
pubmed-meshheading:17683933-Enzyme Inhibitors,
pubmed-meshheading:17683933-G2 Phase,
pubmed-meshheading:17683933-Humans,
pubmed-meshheading:17683933-Mice,
pubmed-meshheading:17683933-Mice, Nude,
pubmed-meshheading:17683933-Neoplasm Transplantation,
pubmed-meshheading:17683933-Poly(ADP-ribose) Polymerases
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pubmed:year |
2007
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pubmed:articleTitle |
Synthesis and biological evaluation of cinnamyl compounds as potent antitumor agents.
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pubmed:affiliation |
Korea Research Institute of Bioscience and Biotechnology, 52 Uendong Yoosung, Daejeon 305-333, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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