Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
2007-10-8
pubmed:abstractText
The prostate contains extremely high concentrations of zinc, which may be required for male reproduction. Although zinc is essential for many cellular functions, excessive zinc induces cellular toxicity in general. However, despite exposure to high zinc environment, prostate cells survive and proliferate. Thus, the aim of this study was to identify the intrinsic molecular species that endow prostate cells with the ability to overcome zinc toxicity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0270-4137
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1514-23
pubmed:meshHeading
pubmed-meshheading:17683079-Animals, pubmed-meshheading:17683079-Apoptosis, pubmed-meshheading:17683079-Blotting, Western, pubmed-meshheading:17683079-Cell Line, Tumor, pubmed-meshheading:17683079-Cell Survival, pubmed-meshheading:17683079-Enzyme Inhibitors, pubmed-meshheading:17683079-Epithelial Cells, pubmed-meshheading:17683079-Humans, pubmed-meshheading:17683079-Hypoxia-Inducible Factor 1, alpha Subunit, pubmed-meshheading:17683079-Immunoenzyme Techniques, pubmed-meshheading:17683079-Male, pubmed-meshheading:17683079-Oxidative Stress, pubmed-meshheading:17683079-Procollagen-Proline Dioxygenase, pubmed-meshheading:17683079-Prostate, pubmed-meshheading:17683079-Prostatic Neoplasms, pubmed-meshheading:17683079-Proteasome Endopeptidase Complex, pubmed-meshheading:17683079-RNA, Small Interfering, pubmed-meshheading:17683079-Rats, pubmed-meshheading:17683079-Reactive Oxygen Species, pubmed-meshheading:17683079-Zinc Compounds
pubmed:year
2007
pubmed:articleTitle
HIF-1alpha promotes survival of prostate cells at a high zinc environment.
pubmed:affiliation
Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't