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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2007-10-29
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pubmed:abstractText |
Recent observations indicate that the delivery of nitric oxide by endothelial nitric oxide synthase (eNOS) is not only critical for metabolic homeostasis, but could also be important for mitochondrial biogenesis, a key organelle for free fatty acid (FFA) oxidation and energy production. Because mice deficient for the gene of eNOS (eNOS(-/-)) have increased triglycerides and FFA levels, in addition to hypertension and insulin resistance, we hypothesized that these knockout mice may have decreased energy expenditure and defective beta-oxidation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1939-327X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2690-6
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pubmed:meshHeading |
pubmed-meshheading:17682093-Animals,
pubmed-meshheading:17682093-Body Size,
pubmed-meshheading:17682093-Calorimetry, Indirect,
pubmed-meshheading:17682093-DNA, Mitochondrial,
pubmed-meshheading:17682093-Energy Metabolism,
pubmed-meshheading:17682093-Epididymis,
pubmed-meshheading:17682093-Fatty Acids, Nonesterified,
pubmed-meshheading:17682093-Lipolysis,
pubmed-meshheading:17682093-Male,
pubmed-meshheading:17682093-Mice,
pubmed-meshheading:17682093-Mice, Knockout,
pubmed-meshheading:17682093-Mitochondria,
pubmed-meshheading:17682093-Mitochondria, Muscle,
pubmed-meshheading:17682093-Muscle, Skeletal,
pubmed-meshheading:17682093-Nitric Oxide Synthase,
pubmed-meshheading:17682093-Nitric Oxide Synthase Type I,
pubmed-meshheading:17682093-Nitric Oxide Synthase Type III,
pubmed-meshheading:17682093-Oxidation-Reduction,
pubmed-meshheading:17682093-Oxygen Consumption,
pubmed-meshheading:17682093-Polymerase Chain Reaction,
pubmed-meshheading:17682093-Triglycerides
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pubmed:year |
2007
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pubmed:articleTitle |
Endothelial nitric oxide synthase (eNOS) knockout mice have defective mitochondrial beta-oxidation.
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pubmed:affiliation |
Department of Cellular Biology and Morphology, University of Lausanne, Lausanne, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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