Linked Life Data

17681374

Source:http://linkedlifedata.com/resource/pubmed/id/17681374

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
31
pubmed:dateCreated
2007-8-21
pubmed:abstractText
Mesenchymal stem cells (MSCs)-based therapy is a promising approach in regenerative medicine and tissue engineering. However, the outcomes of existing treatments have not been satisfactory owing to suboptimal localization to implantation site, poor viability, low engraftment efficacy and lack of functional remodeling of the delivered cells. Therefore, adopting an effective cell delivery modality is among the biggest technological challenges for successful clinical applications of MSC-based therapy. We developed a novel microencapsulation technique producing self-assembled collagen-MSC microspheres and demonstrated that these microspheres could serve as excellent cell delivery devices as they were stable, injectable and able to provide a protective, growth- and migration-supporting matrix to MSCs. We also showed that MSCs could preserve their stem cell nature upon microencapsulation and easily be localized with retained viability upon in vivo implantation. These microspheres present novel cell delivery devices with optimal biological and functional profile that may facilitate clinical applications of MSC-based therapy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0142-9612
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4652-66
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Self-assembled collagen-human mesenchymal stem cell microspheres for regenerative medicine.
pubmed:affiliation
Medical Engineering Program, Department of Mechanical Engineering, The University of Hong Kong, Room 711, Haking Wong Building, Pokfulam Road, Hong Kong Special Administrative Region, China. bpchan@hkucc.hku.hk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't