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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2007-8-21
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pubmed:abstractText |
Etoposide is a potent inducer of mitotic catastrophe; a type of cell death resulting from aberrant mitosis. It is important in p53 negative cells where p53 dependent apoptosis and events at the G1 and G2 cell cycle checkpoints are compromised. Passenger proteins regulate many aspects of mitosis and siRNA interference or direct inhibition of Aurora B kinase results in mitotic catastrophe. However, there is little available data of clinical relevance in leukaemia models. Here, in p53 negative K562 myeloid leukemia cells, etoposide-induced mitotic catastrophe is shown to be time and/or concentration dependent. Survivin and Aurora remained bound to chromosomes. Survivin and Aurora were also associated with Cdk1 and were shown to form complexes, which in pull down experiments, included INCENP. There was no evidence of Aurora B kinase suppression. These data suggests etoposide will complement Aurora B kinase inhibitors currently in clinical trials for cancer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Phytogenic,
http://linkedlifedata.com/resource/pubmed/chemical/BIRC5 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CDC2 Protein Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Etoposide,
http://linkedlifedata.com/resource/pubmed/chemical/Histones,
http://linkedlifedata.com/resource/pubmed/chemical/Inhibitor of Apoptosis Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Microtubule-Associated Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Topoisomerase II Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/aurora kinase
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
361
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
928-33
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17681274-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:17681274-CDC2 Protein Kinase,
pubmed-meshheading:17681274-Cell Death,
pubmed-meshheading:17681274-Chromosomes, Human,
pubmed-meshheading:17681274-Enzyme Inhibitors,
pubmed-meshheading:17681274-Etoposide,
pubmed-meshheading:17681274-G2 Phase,
pubmed-meshheading:17681274-Histones,
pubmed-meshheading:17681274-Humans,
pubmed-meshheading:17681274-Inhibitor of Apoptosis Proteins,
pubmed-meshheading:17681274-K562 Cells,
pubmed-meshheading:17681274-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:17681274-Microtubule-Associated Proteins,
pubmed-meshheading:17681274-Mitosis,
pubmed-meshheading:17681274-Neoplasm Proteins,
pubmed-meshheading:17681274-Protein-Serine-Threonine Kinases,
pubmed-meshheading:17681274-Topoisomerase II Inhibitors
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pubmed:year |
2007
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pubmed:articleTitle |
Cell death in leukemia: passenger protein regulation by topoisomerase inhibitors.
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pubmed:affiliation |
Centre for Haematology, Institute of Cell and Molecular Sciences, Barts and The London School of Medicine and Dentistry, Queen Mary's, University of London, 4 Newark Street, London E1 2AT, UK.
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pubmed:publicationType |
Journal Article
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