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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-8-7
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pubmed:abstractText |
Nonalcoholic steatohepatitis (NASH) is one of the most common causes of liver enzyme elevation in the West. Its prevalence is likely to increase further, paralleling the epidemic increase of the metabolic syndrome. Serotonin degradation by monoamine oxidase A (MAO-A) was recently implicated as an important source of reactive oxygen species. We therefore tested the pathogenetic role of serotonin in a murine model of diet-induced steatohepatitis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alanine Transaminase,
http://linkedlifedata.com/resource/pubmed/chemical/Aspartate Aminotransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Clorgyline,
http://linkedlifedata.com/resource/pubmed/chemical/Methionine,
http://linkedlifedata.com/resource/pubmed/chemical/Monoamine Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Monoamine Oxidase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Plasma Membrane...,
http://linkedlifedata.com/resource/pubmed/chemical/Slc6a4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tph1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tryptophan Hydroxylase
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0016-5085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
133
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
608-18
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17681180-Adult,
pubmed-meshheading:17681180-Aged,
pubmed-meshheading:17681180-Alanine Transaminase,
pubmed-meshheading:17681180-Animals,
pubmed-meshheading:17681180-Aspartate Aminotransferases,
pubmed-meshheading:17681180-Choline Deficiency,
pubmed-meshheading:17681180-Clorgyline,
pubmed-meshheading:17681180-Disease Models, Animal,
pubmed-meshheading:17681180-Fatty Liver,
pubmed-meshheading:17681180-Female,
pubmed-meshheading:17681180-Hepatitis,
pubmed-meshheading:17681180-Humans,
pubmed-meshheading:17681180-Lipid Peroxidation,
pubmed-meshheading:17681180-Liver,
pubmed-meshheading:17681180-Male,
pubmed-meshheading:17681180-Methionine,
pubmed-meshheading:17681180-Mice,
pubmed-meshheading:17681180-Mice, Inbred C57BL,
pubmed-meshheading:17681180-Mice, Knockout,
pubmed-meshheading:17681180-Middle Aged,
pubmed-meshheading:17681180-Mitochondria, Liver,
pubmed-meshheading:17681180-Monoamine Oxidase,
pubmed-meshheading:17681180-Monoamine Oxidase Inhibitors,
pubmed-meshheading:17681180-Oxidative Stress,
pubmed-meshheading:17681180-RNA, Messenger,
pubmed-meshheading:17681180-Reactive Oxygen Species,
pubmed-meshheading:17681180-Serotonin,
pubmed-meshheading:17681180-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:17681180-Severity of Illness Index,
pubmed-meshheading:17681180-Tryptophan Hydroxylase,
pubmed-meshheading:17681180-Up-Regulation
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pubmed:year |
2007
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pubmed:articleTitle |
Serotonin mediates oxidative stress and mitochondrial toxicity in a murine model of nonalcoholic steatohepatitis.
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pubmed:affiliation |
Swiss Hepato-Pancreato-Biliary Center, Department of Visceral and Transplantation Surgery, University Hospital Zurich, Zurich, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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