Linked Life Data

17681045

Source:http://linkedlifedata.com/resource/pubmed/id/17681045

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-8-7
pubmed:abstractText
Peroxisome proliferator-activated receptors (PPAR) are members of the nuclear hormone receptor superfamily. Synthetic ligands to one family member, PPARgamma, are currently widely used as treatment for chronic diseases such as diabetes type II and other insulin resistances, e.g. as seen in polycystic ovary syndrome (PCOS). Moreover, novel approaches employing knock-out mice demonstrated that PPARgamma seems to play a key role in placental and fetal development. This review describes recent insights into the role of PPARs in human reproduction with specific reference to infertility, placental maturation and fetal development as well as disturbed pregnancy. Further, we highlight the current knowledge on synthetic ligands to PPARgamma used as a treatment in women with PCOS.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1046-7408
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
289-310
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Peroxisome proliferator-activated receptors: new players in the field of reproduction.
pubmed:affiliation
Department of Obstetrics and Gynecology, Ludwig-Maximilians-University, Grosshadern, Munich, Germany. bettina.toth@med.uni-muenchen.de
pubmed:publicationType
Journal Article, Review