Linked Life Data

1768066

Source:http://linkedlifedata.com/resource/pubmed/id/1768066

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1992-2-18
pubmed:abstractText
The primary tumors of four human head and neck carcinomas and their xenografts in nude mice were analysed with respect to their histological features and DNA-ploidy level using DNA-flow and DNA-image cytometry. The histological characteristics of the xenografts and the DNA-index did not differ from those of the parent tumors, whereas the growth rate remained unchanged during serial passaging. DNA-flow cytometric analysis revealed the presence of both aneuploid and euploid cells in both parent tumors and their xenografts. During passaging the proportion of aneuploid cells increased. Analysis of the different cell populations by DNA-image cytometry revealed the presence of aneuploid tumor cells and euploid host cells. This study demonstrates that the characteristics of the original tumors in terms of histological features and DNA-ploidy are retained after xenografting.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1943-9
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:articleTitle
DNA--cytometric studies on xenografts of squamous cell carcinomas of the head and neck.
pubmed:affiliation
Department of Otorhinolaryngology, University of Hijmegen, The Netherlands.
pubmed:publicationType
Journal Article