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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2007-8-21
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pubmed:abstractText |
Tetrahydrobiopterin (BH4) deficiency is reported to uncouple the enzymatic activity of endothelial nitric oxide synthase in diabetes mellitus. The mechanism by which diabetes actually leads to BH4 deficiency remains elusive. Here, we demonstrate that diabetes reduced BH4 by increasing 26S proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I (GTPCH), a rate-limiting enzyme in the synthesis of BH4, in parallel with increased formation of both superoxide and peroxynitrite (ONOO-).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/5,6,7,8-tetrahydrobiopterin,
http://linkedlifedata.com/resource/pubmed/chemical/ATP dependent 26S protease,
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Biopterin,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic N-Oxides,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine Proteinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/GTP Cyclohydrolase,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Guanosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Leupeptins,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrogen,
http://linkedlifedata.com/resource/pubmed/chemical/Peroxynitrous Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Proteasome Endopeptidase Complex,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Spin Labels,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin,
http://linkedlifedata.com/resource/pubmed/chemical/benzyloxycarbonylleucyl-leucyl-leuci...,
http://linkedlifedata.com/resource/pubmed/chemical/tempol
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
21
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pubmed:volume |
116
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
944-53
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17679617-Animals,
pubmed-meshheading:17679617-Antioxidants,
pubmed-meshheading:17679617-Aorta,
pubmed-meshheading:17679617-Biopterin,
pubmed-meshheading:17679617-Cells, Cultured,
pubmed-meshheading:17679617-Cyclic N-Oxides,
pubmed-meshheading:17679617-Cysteine Proteinase Inhibitors,
pubmed-meshheading:17679617-Diabetes Mellitus, Experimental,
pubmed-meshheading:17679617-Endothelial Cells,
pubmed-meshheading:17679617-GTP Cyclohydrolase,
pubmed-meshheading:17679617-Glucose,
pubmed-meshheading:17679617-Guanosine Triphosphate,
pubmed-meshheading:17679617-Leupeptins,
pubmed-meshheading:17679617-Mice,
pubmed-meshheading:17679617-Mice, Inbred C57BL,
pubmed-meshheading:17679617-Nitrogen,
pubmed-meshheading:17679617-Organ Culture Techniques,
pubmed-meshheading:17679617-Peroxynitrous Acid,
pubmed-meshheading:17679617-Proteasome Endopeptidase Complex,
pubmed-meshheading:17679617-Reactive Oxygen Species,
pubmed-meshheading:17679617-Spin Labels,
pubmed-meshheading:17679617-Tyrosine,
pubmed-meshheading:17679617-Ubiquitin,
pubmed-meshheading:17679617-Umbilical Veins
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pubmed:year |
2007
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pubmed:articleTitle |
Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus.
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pubmed:affiliation |
Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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