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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2007-8-6
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pubmed:abstractText |
Hypertension often coexists with hyperlipidemia, insulin resistance, and glucose intolerance in metabolic syndrome. Allylmercaptocaptopril is a conjugate of the angiotensin-converting enzyme inhibitor captopril with allicin, an active principle in garlic with multiple beneficial actions on metabolic-syndrome abnormalities. We sought to test the hypothesis that the conjugation of allicin to captopril may confer additional therapeutic actions in metabolic disease.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0895-7061
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
866-74
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17679035-Administration, Oral,
pubmed-meshheading:17679035-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:17679035-Animals,
pubmed-meshheading:17679035-Blood Glucose,
pubmed-meshheading:17679035-Blood Pressure,
pubmed-meshheading:17679035-Captopril,
pubmed-meshheading:17679035-Disease Models, Animal,
pubmed-meshheading:17679035-Dose-Response Relationship, Drug,
pubmed-meshheading:17679035-Drug Combinations,
pubmed-meshheading:17679035-Female,
pubmed-meshheading:17679035-Hypoglycemic Agents,
pubmed-meshheading:17679035-Insulin,
pubmed-meshheading:17679035-Male,
pubmed-meshheading:17679035-Metabolic Syndrome X,
pubmed-meshheading:17679035-Rats,
pubmed-meshheading:17679035-Rats, Inbred SHR,
pubmed-meshheading:17679035-Sulfinic Acids,
pubmed-meshheading:17679035-Treatment Outcome
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pubmed:year |
2007
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pubmed:articleTitle |
Therapeutic actions of allylmercaptocaptopril and captopril in a rat model of metabolic syndrome.
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pubmed:affiliation |
Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4906, USA. pre@po.cwru.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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