Uncoupling protein (UCP) 3 is a mitochondrial inner membrane protein expressed predominantly in glycolytic skeletal muscles. Its role in vivo remains poorly understood. The aim of the present work was to produce a mouse model with moderate overproduction and proper fibre-type distribution of UCP3.
Resistance to high-fat-diet-induced obesity and sexual dimorphism in the metabolic responses of transgenic mice with moderate uncoupling protein 3 overexpression in glycolytic skeletal muscles.
Inserm U858, Laboratoire de recherches sur les obésités, Institut de Médecine Moléculaire de Rangueil, Equipe 4, 1 avenue Jean Poulhès, P.O. Box 84225, 31432, Toulouse Cedex 4, France.
