| pubmed-article:17676044 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17676044 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:17676044 | lifeskim:mentions | umls-concept:C0018894 | lld:lifeskim |
| pubmed-article:17676044 | lifeskim:mentions | umls-concept:C0021764 | lld:lifeskim |
| pubmed-article:17676044 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:17676044 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:17676044 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:17676044 | lifeskim:mentions | umls-concept:C1979963 | lld:lifeskim |
| pubmed-article:17676044 | lifeskim:mentions | umls-concept:C2003903 | lld:lifeskim |
| pubmed-article:17676044 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:17676044 | pubmed:dateCreated | 2007-8-22 | lld:pubmed |
| pubmed-article:17676044 | pubmed:abstractText | T(H)-17 cells are a distinct lineage of proinflammatory T helper cells that are essential for autoimmune disease. In mice, commitment to the T(H)-17 lineage is dependent on transforming growth factor-beta and interleukin 6 (IL-6). Here we demonstrate that IL-23 and IL-1beta induced the development of human T(H)-17 cells expressing IL-17A, IL-17F, IL-22, IL-26, interferon-gamma, the chemokine CCL20 and transcription factor RORgammat. In situ, T(H)-17 cells were identified by expression of the IL-23 receptor and the memory T cell marker CD45RO. Psoriatic skin lesions contained IL-23-producing dendritic cells and were enriched in the cytokines produced by human T(H)-17 cells that promote the production of antimicrobial peptides in human keratinocytes. Our data collectively indicate that human and mouse T(H)-17 cells require distinct factors during differentiation and that human T(H)-17 cells may regulate innate immunity in epithelial cells. | lld:pubmed |
| pubmed-article:17676044 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17676044 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17676044 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17676044 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17676044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17676044 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17676044 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17676044 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:17676044 | pubmed:issn | 1529-2908 | lld:pubmed |
| pubmed-article:17676044 | pubmed:author | pubmed-author:BowmanEdward... | lld:pubmed |
| pubmed-article:17676044 | pubmed:author | pubmed-author:MorelFranckF | lld:pubmed |
| pubmed-article:17676044 | pubmed:author | pubmed-author:LecronJean-Cl... | lld:pubmed |
| pubmed-article:17676044 | pubmed:author | pubmed-author:CuaDaniel JDJ | lld:pubmed |
| pubmed-article:17676044 | pubmed:author | pubmed-author:SmithKathleen... | lld:pubmed |
| pubmed-article:17676044 | pubmed:author | pubmed-author:KasteleinRobe... | lld:pubmed |
| pubmed-article:17676044 | pubmed:author | pubmed-author:de Waal... | lld:pubmed |
| pubmed-article:17676044 | pubmed:author | pubmed-author:ChanJason RJR | lld:pubmed |
| pubmed-article:17676044 | pubmed:author | pubmed-author:BlumenscheinW... | lld:pubmed |
| pubmed-article:17676044 | pubmed:author | pubmed-author:MattsonJeanin... | lld:pubmed |
| pubmed-article:17676044 | pubmed:author | pubmed-author:McClanahanTer... | lld:pubmed |
| pubmed-article:17676044 | pubmed:author | pubmed-author:McKenzieBrent... | lld:pubmed |
| pubmed-article:17676044 | pubmed:author | pubmed-author:BonifaceKatia... | lld:pubmed |
| pubmed-article:17676044 | pubmed:author | pubmed-author:WilsonNichola... | lld:pubmed |
| pubmed-article:17676044 | pubmed:author | pubmed-author:BashamBethB | lld:pubmed |
| pubmed-article:17676044 | pubmed:author | pubmed-author:ChenTaiyingT | lld:pubmed |
| pubmed-article:17676044 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17676044 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:17676044 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17676044 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17676044 | pubmed:pagination | 950-7 | lld:pubmed |
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| pubmed-article:17676044 | pubmed:meshHeading | pubmed-meshheading:17676044... | lld:pubmed |
| pubmed-article:17676044 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17676044 | pubmed:articleTitle | Development, cytokine profile and function of human interleukin 17-producing helper T cells. | lld:pubmed |
| pubmed-article:17676044 | pubmed:affiliation | Department of Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, California 94304-1104, USA. | lld:pubmed |
| pubmed-article:17676044 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17676044 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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