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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2007-8-22
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pubmed:abstractText |
T(H)-17 cells are a distinct lineage of proinflammatory T helper cells that are essential for autoimmune disease. In mice, commitment to the T(H)-17 lineage is dependent on transforming growth factor-beta and interleukin 6 (IL-6). Here we demonstrate that IL-23 and IL-1beta induced the development of human T(H)-17 cells expressing IL-17A, IL-17F, IL-22, IL-26, interferon-gamma, the chemokine CCL20 and transcription factor RORgammat. In situ, T(H)-17 cells were identified by expression of the IL-23 receptor and the memory T cell marker CD45RO. Psoriatic skin lesions contained IL-23-producing dendritic cells and were enriched in the cytokines produced by human T(H)-17 cells that promote the production of antimicrobial peptides in human keratinocytes. Our data collectively indicate that human and mouse T(H)-17 cells require distinct factors during differentiation and that human T(H)-17 cells may regulate innate immunity in epithelial cells.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1529-2908
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pubmed:author |
pubmed-author:BashamBethB,
pubmed-author:BlumenscheinWendy MWM,
pubmed-author:BonifaceKatiaK,
pubmed-author:BowmanEdward PEP,
pubmed-author:ChanJason RJR,
pubmed-author:ChenTaiyingT,
pubmed-author:CuaDaniel JDJ,
pubmed-author:KasteleinRobert ARA,
pubmed-author:LecronJean-ClaudeJC,
pubmed-author:MattsonJeanine DJD,
pubmed-author:McClanahanTerrill KTK,
pubmed-author:McKenzieBrent SBS,
pubmed-author:MorelFranckF,
pubmed-author:SmithKathleenK,
pubmed-author:WilsonNicholas JNJ,
pubmed-author:de Waal MalefytReneR
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
950-7
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pubmed:meshHeading |
pubmed-meshheading:17676044-Antimicrobial Cationic Peptides,
pubmed-meshheading:17676044-Cell Differentiation,
pubmed-meshheading:17676044-Cells, Cultured,
pubmed-meshheading:17676044-Cytokines,
pubmed-meshheading:17676044-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:17676044-Epithelial Cells,
pubmed-meshheading:17676044-Flow Cytometry,
pubmed-meshheading:17676044-Humans,
pubmed-meshheading:17676044-Immunohistochemistry,
pubmed-meshheading:17676044-Interleukin-17,
pubmed-meshheading:17676044-Interleukin-23,
pubmed-meshheading:17676044-Polymerase Chain Reaction,
pubmed-meshheading:17676044-Psoriasis,
pubmed-meshheading:17676044-T-Lymphocyte Subsets,
pubmed-meshheading:17676044-T-Lymphocytes, Helper-Inducer
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pubmed:year |
2007
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pubmed:articleTitle |
Development, cytokine profile and function of human interleukin 17-producing helper T cells.
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pubmed:affiliation |
Department of Discovery Research, Schering-Plough Biopharma (formerly DNAX Research), Palo Alto, California 94304-1104, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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