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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
2007-10-11
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pubmed:databankReference |
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pubmed:abstractText |
Quorum sensing is a regulatory system for controlling gene expression in response to increasing cell density. N-Acylhomoserine lactone (AHL) is produced by gram-negative bacteria, which use it as a quorum-sensing signal molecule. Serratia marcescens is a gram-negative opportunistic pathogen which is responsible for an increasing number of serious nosocomial infections. S. marcescens AS-1 produces N-hexanoyl homoserine lactone (C(6)-HSL) and N-(3-oxohexanoyl) homoserine lactone and regulates prodigiosin production, swarming motility, and biofilm formation by AHL-mediated quorum sensing. We synthesized a series of N-acyl cyclopentylamides with acyl chain lengths ranging from 4 to 12 and estimated their inhibitory effects on prodigiosin production in AS-1. One of these molecules, N-nonanoyl-cyclopentylamide (C(9)-CPA), had a strong inhibitory effect on prodigiosin production. C(9)-CPA also inhibited the swarming motility and biofilm formation of AS-1. A competition assay revealed that C(9)-CPA was able to inhibit quorum sensing at four times the concentration of exogenous C(6)-HSL and was more effective than the previously reported halogenated furanone. Our results demonstrated that C(9)-CPA was an effective quorum-sensing inhibitor for S. marcescens AS-1.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17675425-10844645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17675425-10948095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17675425-11101681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17675425-11932456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17675425-12354232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17675425-12519208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17675425-12573701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17675425-12837389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17675425-12881415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17675425-14729694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17675425-15214641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17675425-15380216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17675425-1548227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17675425-15866935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17675425-16377703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17675425-16483841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17675425-16492560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17675425-16535454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17675425-16574415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17675425-16778355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17675425-17369333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17675425-8932319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17675425-9368530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17675425-9421896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17675425-9717078
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-Butyrolactone,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclopentanes,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Furans,
http://linkedlifedata.com/resource/pubmed/chemical/Prodigiosin,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Ribosomal, 16S,
http://linkedlifedata.com/resource/pubmed/chemical/homoserine lactone
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0099-2240
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6339-44
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pubmed:dateRevised |
2010-9-16
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pubmed:meshHeading |
pubmed-meshheading:17675425-4-Butyrolactone,
pubmed-meshheading:17675425-Bacterial Proteins,
pubmed-meshheading:17675425-Biofilms,
pubmed-meshheading:17675425-Cyclopentanes,
pubmed-meshheading:17675425-DNA, Bacterial,
pubmed-meshheading:17675425-Furans,
pubmed-meshheading:17675425-Gene Expression Regulation, Bacterial,
pubmed-meshheading:17675425-Molecular Sequence Data,
pubmed-meshheading:17675425-Prodigiosin,
pubmed-meshheading:17675425-Quorum Sensing,
pubmed-meshheading:17675425-RNA, Ribosomal, 16S,
pubmed-meshheading:17675425-Sequence Analysis, DNA,
pubmed-meshheading:17675425-Serratia marcescens,
pubmed-meshheading:17675425-Signal Transduction
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pubmed:year |
2007
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pubmed:articleTitle |
Inhibition of quorum sensing in Serratia marcescens AS-1 by synthetic analogs of N-acylhomoserine lactone.
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pubmed:affiliation |
Department of Applied Chemistry, Utsunomiya University, 7-1-2 Yoto, Utsunomiya 321-8585, Japan. morohosi@cc.utsunomiya-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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