|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2007-8-6
|
|
pubmed:abstractText |
We previously found that higher NADPH levels produced by glucose-6-phosphate dehydrogenase (G6PD) can enhance myocardial superoxide generation by NAD(P)H oxidase in a dog model of dilated cardiomyopathy. Therefore, we tested whether G6PD activity is elevated and enhances NADPH level and increases NAD(P)H oxidase-derived superoxide production in the myocardium from patients with heart failure from ischemic cardiomyopathy.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
1532-8414
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
13
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
497-506
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:17675065-Biological Markers,
pubmed-meshheading:17675065-Blotting, Western,
pubmed-meshheading:17675065-Disease Progression,
pubmed-meshheading:17675065-Female,
pubmed-meshheading:17675065-Glucosephosphate Dehydrogenase,
pubmed-meshheading:17675065-Heart Failure,
pubmed-meshheading:17675065-Heart Ventricles,
pubmed-meshheading:17675065-Humans,
pubmed-meshheading:17675065-Hydrogen Peroxide,
pubmed-meshheading:17675065-Luminescent Measurements,
pubmed-meshheading:17675065-Male,
pubmed-meshheading:17675065-Middle Aged,
pubmed-meshheading:17675065-Myocardium,
pubmed-meshheading:17675065-NADPH Oxidase,
pubmed-meshheading:17675065-Oxidative Stress,
pubmed-meshheading:17675065-Prognosis,
pubmed-meshheading:17675065-Severity of Illness Index,
pubmed-meshheading:17675065-Superoxides,
pubmed-meshheading:17675065-Up-Regulation
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Upregulation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase activity increases oxidative stress in failing human heart.
|
|
pubmed:affiliation |
Department of Physiology, New York Medical College, Valhalla, New York 10595, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
