Source:http://linkedlifedata.com/resource/pubmed/id/17674934
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
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| pubmed:dateCreated |
2007-8-6
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| pubmed:abstractText |
It has been shown that gross incorporation of porcine-derived small intestinal submucosa (SiS) is limited at 2 weeks. This study evaluates a technique for improving the early incorporation of implanted eight-ply SiS. Six pigs underwent implantation of SiS on the peritoneal surface using three techniques: suture fixation of stock-perforated SiS, suture fixation of manually perforated SiS, and suture fixation of stock-perforated SiS to mechanically abraded peritoneum. Gross incorporation was evaluated and random samples harvested for tensiometric analysis 2 weeks after implantation. SiS placed onto mechanically abraded peritoneum demonstrated significantly greater gross incorporation than both stock-perforated SiS (100% versus 42%, P = 0.015) and manually perforated SiS (100% versus 50%, P = 0.042). There was no difference in gross incorporation between stock and manually perforated SiS. Using tensiometric analysis, the force required to separate the peritoneum from the SiS implant was significantly greater for the SiS placed onto mechanically abraded peritoneum (4.4 +/- 1.7 kg . f/cm2) than for both the stock-perforated SiS samples (1.0 +/- 0.5 kg x f/cm2) and the needle-perforated SiS samples (1.4 +/- 0.9 kg x f/cm2; P < 0.001). There was no difference between stock and manually perforated SiS at 2 weeks. Mechanical abrasion of the peritoneum before SiS onlay leads to improved gross incorporation 2 weeks after implantation in a porcine model of herniorrhaphy. Long-term studies and histologic analysis are needed to validate this method as a means for improving early incorporation of SiS.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0003-1348
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
73
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
647-51; discussion 651
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| pubmed:meshHeading |
pubmed-meshheading:17674934-Animals,
pubmed-meshheading:17674934-Bioprosthesis,
pubmed-meshheading:17674934-Female,
pubmed-meshheading:17674934-Hernia, Ventral,
pubmed-meshheading:17674934-Intestinal Mucosa,
pubmed-meshheading:17674934-Intestine, Small,
pubmed-meshheading:17674934-Lacerations,
pubmed-meshheading:17674934-Punctures,
pubmed-meshheading:17674934-Suture Techniques,
pubmed-meshheading:17674934-Swine,
pubmed-meshheading:17674934-Tensile Strength
|
| pubmed:year |
2007
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| pubmed:articleTitle |
Mechanical abrasion improves early incorporation of small intestinal submucosa.
|
| pubmed:affiliation |
Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2577, USA. thomas.rauth@vanderbilt.edu
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| pubmed:publicationType |
Journal Article
|