Linked Life Data

17674318

Source:http://linkedlifedata.com/resource/pubmed/id/17674318

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2007-8-3
pubmed:abstractText
Soft-tissue infection is commonly found in patients bitten by Latin American Bothrops snakes. Staphylococcus aureus, which is not present in the mouth of the snake, is frequently isolated from these infections. The effects of B. asper venom on infection with S. aureus were analyzed in a model of infection in envenomated mouse gastrocnemius muscle. Inoculation of 50 colony-forming units (cfu) of S. aureus was enough to cause infection in envenomated muscle, compared with >5x104 cfu without venom. This effect was also achieved by injection of venom myotoxin III (an A(2) phospholipase). A sarA mutant strain in which production of extracellular toxins and enzymes is up-regulated and binding of fibronectin, fibrinogen, and other host proteins is down-regulated was much less virulent than the corresponding parental strain, indicating that the ability of S. aureus to mask itself with host molecules might be more important than the effects of secreted toxins and enzymes in this kind of infection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-1899
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
196
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
748-54
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Increased infectivity of Staphylococcus aureus in an experimental model of snake venom-induced tissue damage.
pubmed:affiliation
Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet, Stockholm, S-171 77, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't