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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2007-10-15
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pubmed:abstractText |
This study investigated the role of long-chain n-3 polyunsaturated fatty acids (LCn-3PUFAs) of muscle phospholipids in the regulation of neonatal metabolism. Twenty-eight piglets were weaned at 2 days of age and raised on one of two milk formulas that consisted of either a control formula supplying 0% or a formula containing 3.5% LCn-3PUFAs until 10 or 28 days of age. There was a developmental decline in the insulin sensitivity of amino acid disposal in control pigs during the first month of life, with a slope of -2.24 micromol.kg(-1).h(-1) (P = 0.01) per unit of insulin increment, as assessed using hyperinsulinemic-euglycemic-euaminoacidemic clamps. LCn-3PUFA feeding blunted this developmental decline, resulting in differing insulin sensitivities (P < 0.001). When protein metabolism was assessed under parenteral feeding-induced hyperinsulinemia, LCn-3PUFAs reduced by 16% whole body oxidative losses of amino acids (from 238 to 231 micromol.kg(-1).h(-1); P = 0.06), allowing 41% more amino acids to accrete into body proteins (from 90 to 127 micromol.kg(-1).h(-1); P = 0.06). The fractional synthetic rate of muscle mixed proteins remained unaltered by the LCn-3PUFA feeding. However, LCn-3PUFAs retarded a developmental increase in the essential-to-nonessential amino acid ratio of the muscle intracellular free pool (P = 0.05). Overall, alterations in metabolism were concomitant with a preferential incorporation of LCn-3PUFAs into muscle total membrane phospholipids (P < 0.001), in contrast to intramuscular triglycerides. These results underscore the potential role of LCn-3PUFAs as regulators of different aspects of protein metabolism in the neonate.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17673528-10331397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17673528-10409133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17673528-10419994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17673528-10523763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17673528-10617575,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17673528-11137568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17673528-11498541,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17673528-11832361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17673528-11832371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17673528-12388131,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17673528-8192673,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17673528-8811878,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17673528-9044434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17673528-9202081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17673528-9576765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17673528-9578384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17673528-9772146
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-2275
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2396-410
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17673528-Amino Acids, Branched-Chain,
pubmed-meshheading:17673528-Animals,
pubmed-meshheading:17673528-Animals, Newborn,
pubmed-meshheading:17673528-Blood Glucose,
pubmed-meshheading:17673528-Fatty Acids,
pubmed-meshheading:17673528-Fatty Acids, Unsaturated,
pubmed-meshheading:17673528-Insulin,
pubmed-meshheading:17673528-Male,
pubmed-meshheading:17673528-Membrane Lipids,
pubmed-meshheading:17673528-Muscle, Skeletal,
pubmed-meshheading:17673528-Parenteral Nutrition, Total,
pubmed-meshheading:17673528-Phenylalanine,
pubmed-meshheading:17673528-Proteins,
pubmed-meshheading:17673528-Sus scrofa
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pubmed:year |
2007
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pubmed:articleTitle |
Long-chain n-3 fatty acids enhance neonatal insulin-regulated protein metabolism in piglets by differentially altering muscle lipid composition.
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pubmed:affiliation |
Department of Animal Science, Faculty of Food Sciences and Agriculture, Laval University Québec, Québec, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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