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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2007-8-2
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pubmed:abstractText |
MHC class I-restricted CD8(+) T cells are necessary to mount an immune response against Mycobacterium tuberculosis. M. tuberculosis antigens can enter MHC class I cross-processing pathways through a number of different mechanisms, including via the uptake of antigen-containing apoptotic vesicles released by infected cells. A study in this issue of the JCI by Hinchey and colleagues shows that M. tuberculosis inhibits host cell apoptosis and thus may interfere with optimal cross-priming and action of CD8(+) T cells (see the related article beginning on page 2279). M. tuberculosis genetically modified to induce apoptosis is shown to be more effective in priming CD8(+) T cells in vivo and therefore may be a more effective vaccine against tuberculosis than the currently utilized M. bovis BCG vaccine.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17671648-10399077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17671648-12368425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17671648-12654780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17671648-12675804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17671648-12758197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17671648-14515128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17671648-15187142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17671648-15385521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17671648-15502839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17671648-16110326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17671648-16214599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17671648-16413927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17671648-16513383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17671648-16547267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17671648-17044198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17671648-17046678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17671648-17160001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17671648-17671656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17671648-7596718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17671648-8287475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17671648-8309034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17671648-9886409
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
117
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2092-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17671648-Adenosine Triphosphatases,
pubmed-meshheading:17671648-Animals,
pubmed-meshheading:17671648-Bacterial Proteins,
pubmed-meshheading:17671648-Cell Line,
pubmed-meshheading:17671648-Gene Deletion,
pubmed-meshheading:17671648-Guinea Pigs,
pubmed-meshheading:17671648-Humans,
pubmed-meshheading:17671648-Macrophages,
pubmed-meshheading:17671648-Membrane Transport Proteins,
pubmed-meshheading:17671648-Mice,
pubmed-meshheading:17671648-Mice, Inbred BALB C,
pubmed-meshheading:17671648-Mycobacterium bovis,
pubmed-meshheading:17671648-Mycobacterium tuberculosis,
pubmed-meshheading:17671648-Superoxide Dismutase,
pubmed-meshheading:17671648-Tuberculosis,
pubmed-meshheading:17671648-Tuberculosis Vaccines
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pubmed:year |
2007
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pubmed:articleTitle |
New TB vaccines: is there a requirement for CD8 T cells?
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pubmed:affiliation |
Tuberculosis Research Unit, Case Western Reserve University and University Hospitals' Case Medical Center, Cleveland, Ohio 44106-4984, USA. whb@case.edu
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pubmed:publicationType |
Journal Article,
Comment,
Research Support, N.I.H., Extramural
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