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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2007-8-2
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pubmed:abstractText |
The effect of cancer immunotherapy on the endogenous immune response against tumors is largely unknown. Therefore, we studied immune responses against murine tumors expressing the glycoprotein (GP) and/or nucleoprotein of lymphocytic choriomeningitis virus (LCMV) with or without adoptive T-cell therapy. In nontreated animals, CTLs specific for different epitopes as well as LCMV-GP-specific antibodies contributed to tumor surveillance. Adoptive immunotherapy with monoclonal CTLs specific for LCMV-gp33 impaired the endogenous tumor-specific antibody and CTL response by targeting antigen cross-presenting cells. As a consequence and in contrast to expectations, immunotherapy enhanced tumor growth. Thus, for certain immunogenic tumors, a reduction of tumor-specific B- and T-cell responses and enhanced tumor growth may be an unwanted consequence of adoptive immunotherapy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chromium,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Nucleoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/RAG-1 protein,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/nucleoprotein peptide 118-126...
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0008-5472
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7467-76
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17671217-Animals,
pubmed-meshheading:17671217-Antigen-Presenting Cells,
pubmed-meshheading:17671217-Chromium,
pubmed-meshheading:17671217-Dendritic Cells,
pubmed-meshheading:17671217-Epitopes, T-Lymphocyte,
pubmed-meshheading:17671217-Fibrosarcoma,
pubmed-meshheading:17671217-Flow Cytometry,
pubmed-meshheading:17671217-Glycoproteins,
pubmed-meshheading:17671217-Homeodomain Proteins,
pubmed-meshheading:17671217-Humans,
pubmed-meshheading:17671217-Immunotherapy, Adoptive,
pubmed-meshheading:17671217-Interferon-gamma,
pubmed-meshheading:17671217-Lymphocytes, Tumor-Infiltrating,
pubmed-meshheading:17671217-Melanoma, Experimental,
pubmed-meshheading:17671217-Mice,
pubmed-meshheading:17671217-Mice, Inbred BALB C,
pubmed-meshheading:17671217-Mice, Inbred C57BL,
pubmed-meshheading:17671217-Nucleoproteins,
pubmed-meshheading:17671217-Peptide Fragments,
pubmed-meshheading:17671217-T-Lymphocytes,
pubmed-meshheading:17671217-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:17671217-Viral Proteins
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pubmed:year |
2007
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pubmed:articleTitle |
Decreased tumor surveillance after adoptive T-cell therapy.
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pubmed:affiliation |
Tumor Immunology, Department of Clinical Research, Inselspital, University of Berne, Berne, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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