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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15 Pt 1
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pubmed:dateCreated |
2007-8-2
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pubmed:abstractText |
Areca nut use is the major cause of oral squamous cell carcinoma (OSCC) in Southern Asians. Areca nut contains a high level of free copper ions. Lysyl oxidase (LOX) is a copper-activated enzyme critical for extracellular matrix organization. Contradictory evidence has been put forward to suggest that LOX may be either an oncogenic or a suppressive element. This study investigated the oncogenic significance of LOX in areca-associated OSCC.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4378-85
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pubmed:meshHeading |
pubmed-meshheading:17671119-Adult,
pubmed-meshheading:17671119-Aged,
pubmed-meshheading:17671119-Aged, 80 and over,
pubmed-meshheading:17671119-Animals,
pubmed-meshheading:17671119-Areca,
pubmed-meshheading:17671119-Carcinoma, Squamous Cell,
pubmed-meshheading:17671119-Cell Movement,
pubmed-meshheading:17671119-Cell Transformation, Neoplastic,
pubmed-meshheading:17671119-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:17671119-Humans,
pubmed-meshheading:17671119-Keratinocytes,
pubmed-meshheading:17671119-Male,
pubmed-meshheading:17671119-Mice,
pubmed-meshheading:17671119-Mice, Nude,
pubmed-meshheading:17671119-Middle Aged,
pubmed-meshheading:17671119-Mouth Mucosa,
pubmed-meshheading:17671119-Mouth Neoplasms,
pubmed-meshheading:17671119-Neoplasm Invasiveness,
pubmed-meshheading:17671119-Plant Extracts,
pubmed-meshheading:17671119-Polymorphism, Genetic,
pubmed-meshheading:17671119-Protein-Lysine 6-Oxidase,
pubmed-meshheading:17671119-RNA, Messenger,
pubmed-meshheading:17671119-RNA, Small Interfering,
pubmed-meshheading:17671119-Tissue Array Analysis,
pubmed-meshheading:17671119-Transplantation, Heterologous,
pubmed-meshheading:17671119-Tumor Cells, Cultured
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pubmed:year |
2007
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pubmed:articleTitle |
Association of expression aberrances and genetic polymorphisms of lysyl oxidase with areca-associated oral tumorigenesis.
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pubmed:affiliation |
Institute of Oral Biology, School of Dentistry, National Yang-Ming University, Taipei, Taiwan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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