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rdf:type |
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lifeskim:mentions |
umls-concept:C0018270,
umls-concept:C0039194,
umls-concept:C0085295,
umls-concept:C0086597,
umls-concept:C0301625,
umls-concept:C1327616,
umls-concept:C1332714,
umls-concept:C1510411,
umls-concept:C1515021,
umls-concept:C1710548,
umls-concept:C2936626
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|
pubmed:issue |
15 Pt 1
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|
pubmed:dateCreated |
2007-8-2
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|
pubmed:abstractText |
Immunosuppression, including that mediated by CD4(+)CD25(high)Foxp3(+) regulatory T cells (Treg), is a characteristic feature of head and neck squamous cell carcinoma (HNSCC). Tregs with a distinct phenotype in tumor-infiltrating lymphocytes (TIL) contribute to local immune suppression.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1078-0432
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4345-54
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17671115-Adult,
pubmed-meshheading:17671115-Aged,
pubmed-meshheading:17671115-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17671115-Carcinoma, Squamous Cell,
pubmed-meshheading:17671115-Cell Proliferation,
pubmed-meshheading:17671115-Female,
pubmed-meshheading:17671115-Flow Cytometry,
pubmed-meshheading:17671115-Forkhead Transcription Factors,
pubmed-meshheading:17671115-Head and Neck Neoplasms,
pubmed-meshheading:17671115-Humans,
pubmed-meshheading:17671115-Immune Tolerance,
pubmed-meshheading:17671115-Immunosuppression,
pubmed-meshheading:17671115-Interleukin-10,
pubmed-meshheading:17671115-Interleukin-2 Receptor alpha Subunit,
pubmed-meshheading:17671115-Lymphocyte Activation,
pubmed-meshheading:17671115-Lymphocytes, Tumor-Infiltrating,
pubmed-meshheading:17671115-Male,
pubmed-meshheading:17671115-Middle Aged,
pubmed-meshheading:17671115-RNA, Messenger,
pubmed-meshheading:17671115-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17671115-T-Lymphocytes, Regulatory,
pubmed-meshheading:17671115-Transforming Growth Factor beta1
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pubmed:year |
2007
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pubmed:articleTitle |
A unique subset of CD4+CD25highFoxp3+ T cells secreting interleukin-10 and transforming growth factor-beta1 mediates suppression in the tumor microenvironment.
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pubmed:affiliation |
University of Pittsburgh Cancer Institute, Pennsylvania 15213-1863, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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