Source:http://linkedlifedata.com/resource/pubmed/id/17669576
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2007-8-31
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| pubmed:abstractText |
Panic disorder is a common anxiety disorder characterized by sudden and recurrent panic attacks. Previous studies have indicated significant genetic contributions and a susceptibility locus for panic disorder has been mapped to human chromosome 7p 15. The receptor for Neuropeptide S (NPS) is located in the same genomic region while NPS is known to produce arousal and anxiolytic-like effects in rodents. Here we report that a coding polymorphism in the Neuropeptide S receptor (NPSR) is associated with panic disorder in male patients of Japanese ancestry. The polymorphism (Asn(107)Ile) results in a gain-of-function of the receptor protein by increasing the agonist sensitivity about tenfold. The allele representing the less active isoform (NPSR Asn(107)) was found under-represented in male panic disorder patients, indicating a potential protective function of the protein. Two unrelated groups of patients diagnosed with schizophrenia or attention-deficit/hyperactivity disorder (ADHD) showed no association of particular NPSR alleles with the disorders. These results provide evidence for a gender-specific effect of NPSR in the pathogenesis of panic disorder.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0278-5846
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
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| pubmed:volume |
31
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1444-8
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| pubmed:meshHeading |
pubmed-meshheading:17669576-Adult,
pubmed-meshheading:17669576-Attention Deficit Disorder with Hyperactivity,
pubmed-meshheading:17669576-Family,
pubmed-meshheading:17669576-Female,
pubmed-meshheading:17669576-Gene Frequency,
pubmed-meshheading:17669576-Genotype,
pubmed-meshheading:17669576-Germany,
pubmed-meshheading:17669576-Humans,
pubmed-meshheading:17669576-Japan,
pubmed-meshheading:17669576-Male,
pubmed-meshheading:17669576-Middle Aged,
pubmed-meshheading:17669576-Panic Disorder,
pubmed-meshheading:17669576-Polymorphism, Genetic,
pubmed-meshheading:17669576-Polymorphism, Single Nucleotide,
pubmed-meshheading:17669576-Receptors, G-Protein-Coupled,
pubmed-meshheading:17669576-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17669576-Schizophrenia,
pubmed-meshheading:17669576-Schizophrenic Psychology,
pubmed-meshheading:17669576-Sex Characteristics
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Gender-specific association of a functional coding polymorphism in the Neuropeptide S receptor gene with panic disorder but not with schizophrenia or attention-deficit/hyperactivity disorder.
|
| pubmed:affiliation |
Department of Pharmacology, University of California Irvine, 360 Med Surge 2, Irvine, CA 92697, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|